ID   IL8H_GAHVM              Reviewed;         134 AA.
AC   Q77MQ6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Viral interleukin-8 homolog;
DE            Short=vIL8;
DE   Flags: Precursor;
GN   Name=MDV078; Synonyms=MDV003;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
RN   [2]
RP   FUNCTION.
RX   PubMed=15078957; DOI=10.1128/jvi.78.9.4753-4760.2004;
RA   Cui X., Lee L.F., Reed W.M., Kung H.J., Reddy S.M.;
RT   "Marek's disease virus-encoded vIL-8 gene is involved in early cytolytic
RT   infection but dispensable for establishment of latency.";
RL   J. Virol. 78:4753-4760(2004).
CC   -!- FUNCTION: Plays a role in the early phase of cytolytic infections
CC       presumably by recruiting host B or T-lymphocytes.
CC       {ECO:0000269|PubMed:15078957}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; AF243438; AAG14256.1; -; Genomic_DNA.
DR   EMBL; AF243438; AAG14290.1; -; Genomic_DNA.
DR   RefSeq; YP_001033918.1; NC_002229.3.
DR   RefSeq; YP_001033995.1; NC_002229.3.
DR   SMR; Q77MQ6; -.
DR   GeneID; 4811462; -.
DR   GeneID; 4811544; -.
DR   KEGG; vg:4811462; -.
DR   KEGG; vg:4811544; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   3: Inferred from homology;
KW   Evasion of host immunity by viral interleukin-like protein;
KW   Host-virus interaction; Reference proteome; Secreted; Signal;
KW   Viral immunoevasion.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..134
FT                   /note="Viral interleukin-8 homolog"
FT                   /id="PRO_0000406503"
SQ   SEQUENCE   134 AA;  14828 MW;  C859CDB868D25190 CRC64;
     MQALLLVLVL FIVQIYLLPG NGISLESLAV DKRCKCVKVT NRPTGLGPII AVDVIPPGIH
     CRRTEIIFAL KKNRKVCVDP EAPWVQQFIK KLERQHRTRK ENLMVGEDGG KSTVGPVKNT
     IEPTPPTIGS HICL