ID   APO1A_CERAT             Reviewed;          81 AA.
AC   P0DPG0;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2018, sequence version 1.
DT   03-AUG-2022, entry version 12.
DE   RecName: Full=Apolipoprotein C-I, acidic form;
DE            Short=Apo-CIA;
DE            Short=ApoC-IA;
DE   AltName: Full=Apolipoprotein C1A;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein C-I, acidic form;
DE              Short=Apo-CIA';
DE              Short=ApoC-IA';
DE   Flags: Precursor;
GN   Name=APOC1A;
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y., Hughes D.S., Murali S., Raveendran M., Korchina V., Wang M.,
RA   Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
RA   Dahdouli M., Dinh H., Doddapaneni H., English A., Firestine M., Gross S.,
RA   Hernandez B., Javaid M., Jayaseelan J., Jones J., Joshi V., Khan Z.,
RA   Kovar C., Lee S., Newsham I., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
RA   Pu L.-L., Puazo M., Qu C., Quiroz J., Raj R., Reid J.G., Santibanez J.,
RA   Scheel M., Sexton D., Shah N., Skinner E., Vee V., Wu Y., Han Y.,
RA   Muzny D.M., Richards S., Worley K.C., Rogers J., Gibbs R.A.;
RT   "Sooty reference genome and diversity panel.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   REVIEW.
RX   PubMed=28757862; DOI=10.1007/s11515-013-1278-7;
RA   Puppione D., Whitelegge J.P.;
RT   "Proteogenomic Review of the Changes in Primate apoC-I during Evolution.";
RL   Front. Biol. 8:533-548(2013).
RN   [3]
RP   GENE DUPLICATION.
RX   PubMed=25160599; DOI=10.1016/j.cbd.2014.08.001;
RA   Puppione D.L.;
RT   "Higher primates, but not New World monkeys, have a duplicate set of
RT   enhancers flanking their apoC-I genes.";
RL   Comp. Biochem. Physiol. 11:45-48(2014).
RN   [4]
RP   IDENTIFICATION.
RA   Puppione D.L.;
RL   Unpublished observations (MAR-2018).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC   -!- MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and
CC       basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and
CC       perhaps also in baboons and macaques. The two genes for ApoC-I arose
CC       through a duplication process that occurred after the divergence of New
CC       World monkeys from the human lineage. In human, the acidic form has
CC       become a pseudogene sometime between the divergence of bonobos and
CC       chimpanzees from the human lineage and the appearance of the
CC       Denisovans. Pseudogenization resulted when the codon for the
CC       penultimate amino acid in the signal sequence was changed to a stop
CC       codon. {ECO:0000303|PubMed:25160599}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}.
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DR   EMBL; JZLG01000000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011935859.1; XM_012080469.1.
DR   RefSeq; XP_011935860.1; XM_012080470.1.
DR   AlphaFoldDB; P0DPG0; -.
DR   SMR; P0DPG0; -.
DR   STRING; 9531.ENSCATP00000011778; -.
DR   Ensembl; ENSCATT00000035904; ENSCATP00000011778; ENSCATG00000030093.
DR   GeneID; 105595127; -.
DR   KEGG; caty:105595127; -.
DR   GeneTree; ENSGT00390000011584; -.
DR   OMA; ELPAKMW; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000030093; Expressed in liver and 1 other tissue.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:Ensembl.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:Ensembl.
DR   GO; GO:0005504; F:fatty acid binding; IEA:Ensembl.
DR   GO; GO:0004859; F:phospholipase inhibitor activity; IEA:Ensembl.
DR   GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR   GO; GO:0034382; P:chylomicron remnant clearance; IEA:Ensembl.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   GO; GO:0032375; P:negative regulation of cholesterol transport; IEA:Ensembl.
DR   GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0051005; P:negative regulation of lipoprotein lipase activity; IEA:Ensembl.
DR   GO; GO:0010900; P:negative regulation of phosphatidylcholine catabolic process; IEA:Ensembl.
DR   GO; GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Ensembl.
DR   GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Ensembl.
DR   GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
DR   GO; GO:0034369; P:plasma lipoprotein particle remodeling; IEA:Ensembl.
DR   GO; GO:0034447; P:very-low-density lipoprotein particle clearance; IEA:Ensembl.
DR   Gene3D; 4.10.260.30; -; 1.
DR   InterPro; IPR043081; ApoC-1_sf.
DR   InterPro; IPR006781; ApoC-I.
DR   PANTHER; PTHR16565; PTHR16565; 1.
DR   Pfam; PF04691; ApoC-I; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Secreted; Signal; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..81
FT                   /note="Apolipoprotein C-I, acidic form"
FT                   /id="PRO_0000444096"
FT   CHAIN           27..81
FT                   /note="Truncated apolipoprotein C-I, acidic form"
FT                   /evidence="ECO:0000250|UniProtKB:P86336"
FT                   /id="PRO_0000444097"
SQ   SEQUENCE   81 AA;  9235 MW;  A1F9608023963E8A CRC64;
     MRLFLSLLVV VLSIVLEGPT PAQGVPDVSN PFDVLEEFGK TLEDNVREFI NLITQSELPA
     KTRDWFSETF RKVKEKLKIN S