IL9R_MOUSE
ID IL9R_MOUSE Reviewed; 468 AA.
AC Q01114;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Interleukin-9 receptor;
DE Short=IL-9 receptor;
DE Short=IL-9R;
DE AltName: CD_antigen=CD129;
DE Flags: Precursor;
GN Name=Il9r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=T-cell;
RX PubMed=1376929; DOI=10.1073/pnas.89.12.5690;
RA Renauld J.-C., Druez C., Kermouni A., Houssiau F., Uyttenhove C.,
RA van Roost E., van Snick J.;
RT "Expression cloning of the murine and human interleukin 9 receptor cDNAs.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:5690-5694(1992).
RN [2]
RP FUNCTION, AND INTERACTION WITH IL9.
RX PubMed=2145361;
RA Druez C., Coulie P., Uyttenhove C., Van Snick J.;
RT "Functional and biochemical characterization of mouse P40/IL-9 receptors.";
RL J. Immunol. 145:2494-2499(1990).
CC -!- FUNCTION: Plays an important role in the immune response against
CC parasites by acting as a receptor of IL9. {ECO:0000269|PubMed:2145361}.
CC -!- SUBUNIT: Interacts with IL9. {ECO:0000269|PubMed:2145361}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein. Secreted.
CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC folding and thereby efficient intracellular transport and cell-surface
CC receptor binding.
CC -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC activation.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 4
CC subfamily. {ECO:0000305}.
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DR EMBL; M84746; AAA37871.1; -; mRNA.
DR CCDS; CCDS24517.1; -.
DR PIR; A45268; A45268.
DR RefSeq; NP_032400.1; NM_008374.2.
DR AlphaFoldDB; Q01114; -.
DR SMR; Q01114; -.
DR STRING; 10090.ENSMUSP00000119557; -.
DR GlyGen; Q01114; 2 sites.
DR PhosphoSitePlus; Q01114; -.
DR PaxDb; Q01114; -.
DR PRIDE; Q01114; -.
DR Antibodypedia; 4187; 443 antibodies from 33 providers.
DR DNASU; 16199; -.
DR Ensembl; ENSMUST00000145401; ENSMUSP00000118204; ENSMUSG00000020279.
DR GeneID; 16199; -.
DR KEGG; mmu:16199; -.
DR UCSC; uc007iix.2; mouse.
DR CTD; 3581; -.
DR MGI; MGI:96564; Il9r.
DR VEuPathDB; HostDB:ENSMUSG00000020279; -.
DR eggNOG; ENOG502SB39; Eukaryota.
DR GeneTree; ENSGT00510000049125; -.
DR HOGENOM; CLU_614777_0_0_1; -.
DR InParanoid; Q01114; -.
DR OMA; CWGVSVP; -.
DR OrthoDB; 774083at2759; -.
DR Reactome; R-MMU-8985947; Interleukin-9 signaling.
DR BioGRID-ORCS; 16199; 2 hits in 74 CRISPR screens.
DR PRO; PR:Q01114; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q01114; protein.
DR Bgee; ENSMUSG00000020279; Expressed in spermatocyte and 18 other tissues.
DR ExpressionAtlas; Q01114; baseline and differential.
DR Genevisible; Q01114; MM.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0019983; F:interleukin-9 binding; IBA:GO_Central.
DR GO; GO:0004919; F:interleukin-9 receptor activity; IGI:MGI.
DR GO; GO:0030183; P:B cell differentiation; IGI:MGI.
DR GO; GO:0042100; P:B cell proliferation; IGI:MGI.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0016064; P:immunoglobulin mediated immune response; IGI:MGI.
DR GO; GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:MGI.
DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IGI:MGI.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Secreted; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..37
FT /evidence="ECO:0000255"
FT CHAIN 38..468
FT /note="Interleukin-9 receptor"
FT /id="PRO_0000010912"
FT TOPO_DOM 38..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..468
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 148..256
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 407..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 244..248
FT /note="WSXWS motif"
FT MOTIF 301..309
FT /note="Box 1 motif"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 155
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 468 AA; 52261 MW; BBE7179FD72E29A5 CRC64;
MALGRCIAEG WTLERVAVKQ VSWFLIYSWV CSGVCRGVSV PEQGGGGQKA GAFTCLSNSI
YRIDCHWSAP ELGQESRAWL LFTSNQVTEI KHKCTFWDSM CTLVLPKEEV FLPFDNFTIT
LHRCIMGQEQ VSLVDSQYLP RRHIKLDPPS DLQSNVSSGR CVLTWGINLA LEPLITSLSY
ELAFKRQEEA WEARHKDRIV GVTWLILEAV ELNPGSIYEA RLRVQMTLES YEDKTEGEYY
KSHWSEWSQP VSFPSPQRRQ GLLVPRWQWS ASILVVVPIF LLLTGFVHLL FKLSPRLKRI
FYQNIPSPEA FFHPLYSVYH GDFQSWTGAR RAGPQARQNG VSTSSAGSES SIWEAVATLT
YSPACPVQFA CLKWEATAPG FPGLPGSEHV LPAGCLELEG QPSAYLPQED WAPLGSARPP
PPDSDSGSSD YCMLDCCEEC HLSAFPGHTE SPELTLAQPV ALPVSSRA
