IL9_HUMAN
ID IL9_HUMAN Reviewed; 144 AA.
AC P15248;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Interleukin-9;
DE Short=IL-9;
DE AltName: Full=Cytokine P40;
DE AltName: Full=T-cell growth factor P40;
DE Flags: Precursor;
GN Name=IL9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2508790;
RA Yang Y.C., Ricciardi S., Ciarletta A., Calvetti J.A., Kelleher K.,
RA Clark S.C.;
RT "Expression cloning of cDNA encoding a novel human hematopoietic growth
RT factor: human homologue of murine T-cell growth factor P40.";
RL Blood 74:1880-1884(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2129501; DOI=10.1016/1043-4666(90)90037-t;
RA Renauld J.-C., Goethals A., Houssiau F., van Roost E., van Snick J.;
RT "Cloning and expression of a cDNA for the human homolog of mouse T cell and
RT mast cell growth factor P40.";
RL Cytokine 2:9-12(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1971295;
RA Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E.,
RA van Snick J.;
RT "Human P40/IL-9. Expression in activated CD4+ T cells, genomic
RT organization, and comparison with the mouse gene.";
RL J. Immunol. 144:4235-4241(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Leukocyte;
RX PubMed=1901233;
RA Kelleher K., Bean K., Clark S.C., Leung W.Y., Yang-Feng T.L., Chen J.W.,
RA Lin P.F., Luo W., Yang Y.C.;
RT "Human interleukin-9: genomic sequence, chromosomal location, and sequences
RT essential for its expression in human T-cell leukemia virus (HTLV)-I-
RT transformed human T cells.";
RL Blood 77:1436-1441(1991).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT MET-117.
RG SeattleSNPs variation discovery resource;
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION.
RX PubMed=29742432; DOI=10.1016/j.celrep.2018.04.034;
RA Renga G., Moretti S., Oikonomou V., Borghi M., Zelante T., Paolicelli G.,
RA Costantini C., De Zuani M., Villella V.R., Raia V., Del Sordo R.,
RA Bartoli A., Baldoni M., Renauld J.C., Sidoni A., Garaci E., Maiuri L.,
RA Pucillo C., Romani L.;
RT "IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and
RT Pathogenesis in the Gut.";
RL Cell Rep. 23:1767-1778(2018).
CC -!- FUNCTION: Multifunctional cytokine secreted mainly by T-helper 2
CC lymphocytes and also mast cells or NKT cells that plays important roles
CC in the immune response against parasites (PubMed:29742432). Affects
CC intestinal epithelial permeability and adaptive immunity
CC (PubMed:29742432). In addition, induces the differentiation of specific
CC T-cell subsets such as IL-17 producing helper T-cells (TH17) and also
CC proliferation and differentiation of mast cells. Mechanistically,
CC exerts its biological effects through a receptor composed of IL9R
CC subunit and a signal transducing subunit IL2RG. Receptor stimulation
CC results in the rapid activation of JAK1 and JAK3 kinase activities
CC leading to STAT1, STAT3 and STAT5-mediated transcriptional programs.
CC Induction of differentiation genes seems to be mediated by STAT1 alone,
CC while protection of cells from apoptosis depends on STAT3 and STAT5.
CC {ECO:0000250|UniProtKB:P15247, ECO:0000269|PubMed:29742432}.
CC -!- SUBUNIT: Interacts with IL9R. Interacts with IL2RG.
CC {ECO:0000250|UniProtKB:P15247}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-7/IL-9 family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-9 entry;
CC URL="https://en.wikipedia.org/wiki/Interleukin_9";
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/il9/";
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DR EMBL; M30134; AAA36400.1; -; mRNA.
DR EMBL; X17543; CAA35581.1; -; mRNA.
DR EMBL; S63356; AAB19823.1; -; mRNA.
DR EMBL; M30135; AAA35887.1; -; Genomic_DNA.
DR EMBL; M86593; AAA59161.1; -; Genomic_DNA.
DR EMBL; AF361105; AAK26666.1; -; Genomic_DNA.
DR EMBL; AC002428; AAB66904.1; -; Genomic_DNA.
DR EMBL; AC004763; AAC17735.1; -; Genomic_DNA.
DR EMBL; BC066283; AAH66283.1; -; mRNA.
DR EMBL; BC066285; AAH66285.1; -; mRNA.
DR EMBL; BC066286; AAH66286.1; -; mRNA.
DR CCDS; CCDS4189.1; -.
DR PIR; A60480; A60480.
DR RefSeq; NP_000581.1; NM_000590.1.
DR AlphaFoldDB; P15248; -.
DR BioGRID; 109792; 1.
DR DIP; DIP-3155N; -.
DR STRING; 9606.ENSP00000274520; -.
DR ChEMBL; CHEMBL3712932; -.
DR GlyGen; P15248; 4 sites.
DR iPTMnet; P15248; -.
DR PhosphoSitePlus; P15248; -.
DR BioMuta; IL9; -.
DR DMDM; 124362; -.
DR PaxDb; P15248; -.
DR PRIDE; P15248; -.
DR ABCD; P15248; 17 sequenced antibodies.
DR Antibodypedia; 14762; 627 antibodies from 39 providers.
DR DNASU; 3578; -.
DR Ensembl; ENST00000274520.2; ENSP00000274520.1; ENSG00000145839.2.
DR GeneID; 3578; -.
DR KEGG; hsa:3578; -.
DR MANE-Select; ENST00000274520.2; ENSP00000274520.1; NM_000590.2; NP_000581.1.
DR UCSC; uc003lbb.1; human.
DR CTD; 3578; -.
DR DisGeNET; 3578; -.
DR GeneCards; IL9; -.
DR HGNC; HGNC:6029; IL9.
DR HPA; ENSG00000145839; Not detected.
DR MIM; 146931; gene.
DR neXtProt; NX_P15248; -.
DR OpenTargets; ENSG00000145839; -.
DR PharmGKB; PA29845; -.
DR VEuPathDB; HostDB:ENSG00000145839; -.
DR eggNOG; ENOG502TDE1; Eukaryota.
DR GeneTree; ENSGT00390000015384; -.
DR HOGENOM; CLU_150120_0_0_1; -.
DR InParanoid; P15248; -.
DR OMA; CPFFSCE; -.
DR OrthoDB; 1444257at2759; -.
DR PhylomeDB; P15248; -.
DR TreeFam; TF336367; -.
DR PathwayCommons; P15248; -.
DR Reactome; R-HSA-8985947; Interleukin-9 signaling.
DR SignaLink; P15248; -.
DR SIGNOR; P15248; -.
DR BioGRID-ORCS; 3578; 6 hits in 1056 CRISPR screens.
DR GeneWiki; Interleukin_9; -.
DR GenomeRNAi; 3578; -.
DR Pharos; P15248; Tbio.
DR PRO; PR:P15248; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; P15248; protein.
DR Bgee; ENSG00000145839; Expressed in tibial nerve and 56 other tissues.
DR Genevisible; P15248; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005140; F:interleukin-9 receptor binding; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR GO; GO:0016064; P:immunoglobulin mediated immune response; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; TAS:ProtInc.
DR GO; GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:ProtInc.
DR GO; GO:0032754; P:positive regulation of interleukin-5 production; ISS:UniProtKB.
DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0046425; P:regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR InterPro; IPR018049; IL-7/IL-9_CS.
DR InterPro; IPR020447; IL-9.
DR PANTHER; PTHR16926; PTHR16926; 1.
DR PRINTS; PR01926; INTERLEUKIN9.
DR PROSITE; PS00255; INTERLEUKIN_7_9; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Glycoprotein; Growth factor; Pyrrolidone carboxylic acid;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT CHAIN 19..144
FT /note="Interleukin-9"
FT /id="PRO_0000015627"
FT MOD_RES 19
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P15247"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 117
FT /note="T -> M (in dbSNP:rs2069885)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_013079"
SQ SEQUENCE 144 AA; 15909 MW; 2EAA08690558ECAB CRC64;
MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN VTSCLCLGIP
SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK NNKCPYFSCE QPCNQTTAGN
ALTFLKSLLE IFQKEKMRGM RGKI
