ID   ILA1_CAEEL              Reviewed;          76 AA.
AC   Q21507;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Probable insulin-like peptide alpha-type 1;
DE   Flags: Precursor;
GN   Name=ins-21; ORFNames=M04D8.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   SIMILARITY TO INSULIN.
RX   PubMed=9548970; DOI=10.1101/gr.8.4.348;
RA   Duret L., Guex N., Peitsch M.C., Bairoch A.;
RT   "New insulin-like proteins with atypical disulfide bond pattern
RT   characterized in Caenorhabditis elegans by comparative sequence analysis
RT   and homology modeling.";
RL   Genome Res. 8:348-353(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; Z32682; CAA83610.2; -; Genomic_DNA.
DR   PIR; S43588; S43588.
DR   RefSeq; NP_499222.2; NM_066821.2.
DR   AlphaFoldDB; Q21507; -.
DR   SMR; Q21507; -.
DR   STRING; 6239.M04D8.1; -.
DR   PaxDb; Q21507; -.
DR   EnsemblMetazoa; M04D8.1.1; M04D8.1.1; WBGene00002104.
DR   GeneID; 191689; -.
DR   KEGG; cel:CELE_M04D8.1; -.
DR   UCSC; M04D8.1; c. elegans.
DR   CTD; 191689; -.
DR   WormBase; M04D8.1; CE35999; WBGene00002104; ins-21.
DR   eggNOG; ENOG502TIT9; Eukaryota.
DR   GeneTree; ENSGT00970000197132; -.
DR   HOGENOM; CLU_2673472_0_0_1; -.
DR   InParanoid; Q21507; -.
DR   OMA; CPDMCLT; -.
DR   OrthoDB; 1883495at2759; -.
DR   PhylomeDB; Q21507; -.
DR   PRO; PR:Q21507; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00002104; Expressed in larva and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..76
FT                   /note="Probable insulin-like peptide alpha-type 1"
FT                   /id="PRO_0000016213"
FT   DISULFID        32..60
FT                   /evidence="ECO:0000255"
FT   DISULFID        44..73
FT                   /evidence="ECO:0000255"
FT   DISULFID        48..74
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   76 AA;  8856 MW;  CC5C5AC4978EA4BB CRC64;
     MKTYSFFVLF IVFIFFISSS KSHSKKHVRF LCATKAVKHI RKVCPDMCLT GEEVEVNEFC
     KMGYSDSQIK YICCPE