ID   ILA2_CAEEL              Reviewed;          83 AA.
AC   Q21508;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Probable insulin-like peptide alpha-type 2;
DE   Flags: Precursor;
GN   Name=ins-22; ORFNames=M04D8.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   SIMILARITY TO INSULIN, AND 3D-STRUCTURE MODELING.
RX   PubMed=9548970; DOI=10.1101/gr.8.4.348;
RA   Duret L., Guex N., Peitsch M.C., Bairoch A.;
RT   "New insulin-like proteins with atypical disulfide bond pattern
RT   characterized in Caenorhabditis elegans by comparative sequence analysis
RT   and homology modeling.";
RL   Genome Res. 8:348-353(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; Z32682; CAA83611.1; -; Genomic_DNA.
DR   PIR; S43589; S43589.
DR   RefSeq; NP_499223.1; NM_066822.3.
DR   AlphaFoldDB; Q21508; -.
DR   BioGRID; 56189; 2.
DR   STRING; 6239.M04D8.2; -.
DR   PaxDb; Q21508; -.
DR   EnsemblMetazoa; M04D8.2.1; M04D8.2.1; WBGene00002105.
DR   GeneID; 191690; -.
DR   KEGG; cel:CELE_M04D8.2; -.
DR   UCSC; M04D8.2.2; c. elegans.
DR   CTD; 191690; -.
DR   WormBase; M04D8.2; CE00577; WBGene00002105; ins-22.
DR   eggNOG; ENOG502TISA; Eukaryota.
DR   GeneTree; ENSGT00970000197132; -.
DR   HOGENOM; CLU_2673472_0_0_1; -.
DR   InParanoid; Q21508; -.
DR   OMA; EYCSMGF; -.
DR   PhylomeDB; Q21508; -.
DR   PRO; PR:Q21508; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00002105; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..83
FT                   /note="Probable insulin-like peptide alpha-type 2"
FT                   /id="PRO_0000016214"
FT   DISULFID        32..66
FT                   /evidence="ECO:0000255"
FT   DISULFID        44..79
FT                   /evidence="ECO:0000255"
FT   DISULFID        54..80
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   83 AA;  9341 MW;  7EAB87D63ECCB6A6 CRC64;
     MHTTTILICF FIFLVQVSTM DAHTDKYVRT LCGKTAIRNI ANLCPPKPEM KGICSTGEYP
     SITEYCSMGF SDSQIKFMCC DNQ