ID   ILA3_CAEEL              Reviewed;          76 AA.
AC   Q21506;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Probable insulin-like peptide alpha-type 3;
DE   Flags: Precursor;
GN   Name=ins-23; ORFNames=M04D8.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   SIMILARITY TO INSULIN, AND 3D-STRUCTURE MODELING.
RX   PubMed=9548970; DOI=10.1101/gr.8.4.348;
RA   Duret L., Guex N., Peitsch M.C., Bairoch A.;
RT   "New insulin-like proteins with atypical disulfide bond pattern
RT   characterized in Caenorhabditis elegans by comparative sequence analysis
RT   and homology modeling.";
RL   Genome Res. 8:348-353(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z32682; CAA83609.1; -; Genomic_DNA.
DR   PIR; S43590; S43590.
DR   RefSeq; NP_499224.1; NM_066823.1.
DR   AlphaFoldDB; Q21506; -.
DR   SMR; Q21506; -.
DR   STRING; 6239.M04D8.3; -.
DR   PaxDb; Q21506; -.
DR   EnsemblMetazoa; M04D8.3.1; M04D8.3.1; WBGene00002106.
DR   GeneID; 191691; -.
DR   KEGG; cel:CELE_M04D8.3; -.
DR   UCSC; M04D8.3; c. elegans.
DR   CTD; 191691; -.
DR   WormBase; M04D8.3; CE00578; WBGene00002106; ins-23.
DR   eggNOG; ENOG502TISA; Eukaryota.
DR   GeneTree; ENSGT00970000197132; -.
DR   HOGENOM; CLU_2673472_0_0_1; -.
DR   InParanoid; Q21506; -.
DR   OrthoDB; 1858624at2759; -.
DR   PhylomeDB; Q21506; -.
DR   PRO; PR:Q21506; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00002106; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   InterPro; IPR003235; Nem_insulin-like_b-type.
DR   Pfam; PF03488; Ins_beta; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..76
FT                   /note="Probable insulin-like peptide alpha-type 3"
FT                   /id="PRO_0000016215"
FT   DISULFID        28..58
FT                   /evidence="ECO:0000255"
FT   DISULFID        40..71
FT                   /evidence="ECO:0000255"
FT   DISULFID        46..72
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   76 AA;  8316 MW;  1E883C749E5C8669 CRC64;
     MFVLLIILSI ILAQVTDAHS ELHVRRVCGT AIIKNIMRLC PGVPACENGE VPSPTEYCSM
     GYSDSQVKYL CCPTSQ