APO1A_GORGO
ID APO1A_GORGO Reviewed; 83 AA.
AC P0CF78;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 1.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Apolipoprotein C-I, acidic form;
DE Short=Apo-CIA;
DE Short=ApoC-IA;
DE AltName: Full=Apolipoprotein C1A;
DE Contains:
DE RecName: Full=Truncated apolipoprotein C-I, acidic form;
DE Short=Apo-CIA';
DE Short=ApoC-IA';
DE Flags: Precursor;
GN Name=APOC1A;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP IDENTIFICATION.
RA Puppione D.L.;
RL Unpublished observations (MAR-2010).
RN [2]
RP REVIEW.
RX PubMed=28757862; DOI=10.1007/s11515-013-1278-7;
RA Puppione D., Whitelegge J.P.;
RT "Proteogenomic Review of the Changes in Primate apoC-I during Evolution.";
RL Front. Biol. 8:533-548(2013).
RN [3]
RP GENE DUPLICATION.
RX PubMed=25160599; DOI=10.1016/j.cbd.2014.08.001;
RA Puppione D.L.;
RT "Higher primates, but not New World monkeys, have a duplicate set of
RT enhancers flanking their apoC-I genes.";
RL Comp. Biochem. Physiol. 11:45-48(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC -!- MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and
CC basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and
CC perhaps also in baboons and macaques. The two genes for ApoC-I arose
CC through a duplication process that occurred after the divergence of New
CC World monkeys from the human lineage. In human, the acidic form has
CC become a pseudogene sometime between the divergence of bonobos and
CC chimpanzees from the human lineage and the appearance of the
CC Denisovans. Pseudogenization resulted when the codon for the
CC penultimate amino acid in the signal sequence was changed to a stop
CC codon. {ECO:0000303|PubMed:25160599}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}.
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DR RefSeq; XP_018870626.1; XM_019015081.1.
DR AlphaFoldDB; P0CF78; -.
DR SMR; P0CF78; -.
DR Ensembl; ENSGGOT00000067328; ENSGGOP00000030983; ENSGGOG00000022078.
DR GeneID; 109024151; -.
DR KEGG; ggo:109024151; -.
DR eggNOG; ENOG502SEU4; Eukaryota.
DR GeneTree; ENSGT00390000011584; -.
DR HOGENOM; CLU_160094_1_0_1; -.
DR InParanoid; P0CF78; -.
DR OMA; ELPAKMW; -.
DR OrthoDB; 1558708at2759; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000022078; Expressed in liver and 2 other tissues.
DR GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR GO; GO:0004859; F:phospholipase inhibitor activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0032375; P:negative regulation of cholesterol transport; IBA:GO_Central.
DR GO; GO:0050995; P:negative regulation of lipid catabolic process; IBA:GO_Central.
DR GO; GO:0051005; P:negative regulation of lipoprotein lipase activity; IBA:GO_Central.
DR GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IBA:GO_Central.
DR GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR GO; GO:0034447; P:very-low-density lipoprotein particle clearance; IBA:GO_Central.
DR Gene3D; 4.10.260.30; -; 1.
DR InterPro; IPR043081; ApoC-1_sf.
DR InterPro; IPR006781; ApoC-I.
DR PANTHER; PTHR16565; PTHR16565; 1.
DR Pfam; PF04691; ApoC-I; 1.
PE 3: Inferred from homology;
KW Lipid transport; Reference proteome; Secreted; Signal; Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..83
FT /note="Apolipoprotein C-I, acidic form"
FT /id="PRO_0000394027"
FT CHAIN 29..83
FT /note="Truncated apolipoprotein C-I, acidic form"
FT /evidence="ECO:0000250|UniProtKB:P86336"
FT /id="PRO_0000394028"
SQ SEQUENCE 83 AA; 9373 MW; 21CCA94D53B8512F CRC64;
MRLFLSLPVL VVVLSMVLEG PAPAQGAPEV SNPFDGLEEL GKTLEDNTQE LINRITQSEL
PAKMWDWFSE TFRKVKEKLK IDS