ID   ILB2_CAEEL              Reviewed;         106 AA.
AC   Q09627;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Probable insulin-like peptide beta-type 2;
DE   Flags: Precursor;
GN   Name=ins-2; ORFNames=ZK75.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   SIMILARITY TO INSULIN.
RX   PubMed=9548970; DOI=10.1101/gr.8.4.348;
RA   Duret L., Guex N., Peitsch M.C., Bairoch A.;
RT   "New insulin-like proteins with atypical disulfide bond pattern
RT   characterized in Caenorhabditis elegans by comparative sequence analysis
RT   and homology modeling.";
RL   Genome Res. 8:348-353(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; FO080104; CCD61235.1; -; Genomic_DNA.
DR   PIR; T27987; T27987.
DR   RefSeq; NP_495194.1; NM_062793.1.
DR   AlphaFoldDB; Q09627; -.
DR   SMR; Q09627; -.
DR   PaxDb; Q09627; -.
DR   PeptideAtlas; Q09627; -.
DR   EnsemblMetazoa; ZK75.2.1; ZK75.2.1; WBGene00002085.
DR   GeneID; 191217; -.
DR   KEGG; cel:CELE_ZK75.2; -.
DR   UCSC; ZK75.2; c. elegans.
DR   CTD; 191217; -.
DR   WormBase; ZK75.2; CE02101; WBGene00002085; ins-2.
DR   eggNOG; ENOG502TIEQ; Eukaryota.
DR   HOGENOM; CLU_154797_1_0_1; -.
DR   InParanoid; Q09627; -.
DR   OMA; SHICCIK; -.
DR   OrthoDB; 1638794at2759; -.
DR   PhylomeDB; Q09627; -.
DR   PRO; PR:Q09627; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00002085; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:1905910; P:negative regulation of dauer entry; IGI:UniProtKB.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR003235; Nem_insulin-like_b-type.
DR   Pfam; PF03488; Ins_beta; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   PROPEP          16..56
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016218"
FT   CHAIN           57..106
FT                   /note="Probable insulin-like peptide beta-type 2"
FT                   /id="PRO_0000016219"
FT   DISULFID        58..86
FT                   /evidence="ECO:0000255"
FT   DISULFID        70..99
FT                   /evidence="ECO:0000255"
FT   DISULFID        73..100
FT                   /evidence="ECO:0000255"
FT   DISULFID        85..90
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   106 AA;  12033 MW;  24A36BFD57720977 CRC64;
     MNAIIFCLLF TTVTATYEVF GKGIEHRNEH LIINQLDIIP VESTPTPNRA SRVQKRLCGR
     RLILFMLATC GECDTDSSED LSHICCIKQC DVQDIIRVCC PNSFRK