ID   ILB6_CAEEL              Reviewed;         100 AA.
AC   P56173; Q23631;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Putative insulin-like peptide beta-type 6;
DE   Flags: Precursor;
GN   Name=ins-5; ORFNames=ZK84.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   SIMILARITY TO INSULIN.
RX   PubMed=9548970; DOI=10.1101/gr.8.4.348;
RA   Duret L., Guex N., Peitsch M.C., Bairoch A.;
RT   "New insulin-like proteins with atypical disulfide bond pattern
RT   characterized in Caenorhabditis elegans by comparative sequence analysis
RT   and homology modeling.";
RL   Genome Res. 8:348-353(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; FO081688; CCD73332.1; -; Genomic_DNA.
DR   PIR; T29013; T29013.
DR   RefSeq; NP_495197.4; NM_062796.4.
DR   AlphaFoldDB; P56173; -.
DR   SMR; P56173; -.
DR   STRING; 6239.ZK84.3; -.
DR   PaxDb; P56173; -.
DR   EnsemblMetazoa; ZK84.3.1; ZK84.3.1; WBGene00002088.
DR   EnsemblMetazoa; ZK84.3.2; ZK84.3.2; WBGene00002088.
DR   GeneID; 191686; -.
DR   UCSC; ZK84.3; c. elegans.
DR   CTD; 191686; -.
DR   WormBase; ZK84.3; CE44931; WBGene00002088; ins-5.
DR   GeneTree; ENSGT00970000196018; -.
DR   HOGENOM; CLU_2308569_0_0_1; -.
DR   PhylomeDB; P56173; -.
DR   PRO; PR:P56173; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00002088; Expressed in larva and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0040024; P:dauer larval development; IGI:UniProtKB.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR003235; Nem_insulin-like_b-type.
DR   Pfam; PF03488; Ins_beta; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..100
FT                   /note="Putative insulin-like peptide beta-type 6"
FT                   /id="PRO_0000221094"
FT   DISULFID        54..83
FT                   /evidence="ECO:0000250"
FT   DISULFID        66..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        70..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        82..87
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   100 AA;  10922 MW;  0B6962AA98065712 CRC64;
     MHSIVALMLI GTILPIAALH QKHQGFILSS SDSTGNQPMD AISRADRHTN YRSCALRLIP
     HVWSVCGDAC QPQNGIDVAQ KCCSTDCSSD YIKEICCPFD