ID   APO1A_MACMU             Reviewed;          81 AA.
AC   G8F204;
DT   06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Apolipoprotein C-I, acidic form;
DE            Short=Apo-CIA;
DE            Short=ApoC-IA;
DE   AltName: Full=Apolipoprotein C1A;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein C-I, acidic form;
DE              Short=Apo-CIA';
DE              Short=ApoC-IA';
DE   Flags: Precursor;
GN   Name=APOC1A;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
RN   [2]
RP   REVIEW.
RX   PubMed=28757862; DOI=10.1007/s11515-013-1278-7;
RA   Puppione D., Whitelegge J.P.;
RT   "Proteogenomic Review of the Changes in Primate apoC-I during Evolution.";
RL   Front. Biol. 8:533-548(2013).
RN   [3]
RP   GENE DUPLICATION.
RX   PubMed=25160599; DOI=10.1016/j.cbd.2014.08.001;
RA   Puppione D.L.;
RT   "Higher primates, but not New World monkeys, have a duplicate set of
RT   enhancers flanking their apoC-I genes.";
RL   Comp. Biochem. Physiol. 11:45-48(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC   -!- MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and
CC       basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and
CC       perhaps also in baboons and macaques. The two genes for ApoC-I arose
CC       through a duplication process that occurred after the divergence of New
CC       World monkeys from the human lineage. In human, the acidic form has
CC       become a pseudogene sometime between the divergence of bonobos and
CC       chimpanzees from the human lineage and the appearance of the
CC       Denisovans. Pseudogenization resulted when the codon for the
CC       penultimate amino acid in the signal sequence was changed to a stop
CC       codon. {ECO:0000303|PubMed:25160599}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}.
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DR   EMBL; JH292475; EHH25653.1; -; Genomic_DNA.
DR   AlphaFoldDB; G8F204; -.
DR   SMR; G8F204; -.
DR   Proteomes; UP000006718; Unplaced.
DR   Proteomes; UP000013456; Unassembled WGS sequence.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR   GO; GO:0004859; F:phospholipase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   GO; GO:0032375; P:negative regulation of cholesterol transport; IBA:GO_Central.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IBA:GO_Central.
DR   GO; GO:0051005; P:negative regulation of lipoprotein lipase activity; IBA:GO_Central.
DR   GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IBA:GO_Central.
DR   GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR   GO; GO:0034447; P:very-low-density lipoprotein particle clearance; IBA:GO_Central.
DR   Gene3D; 4.10.260.30; -; 1.
DR   InterPro; IPR043081; ApoC-1_sf.
DR   InterPro; IPR006781; ApoC-I.
DR   PANTHER; PTHR16565; PTHR16565; 1.
DR   Pfam; PF04691; ApoC-I; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Secreted; Signal; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..81
FT                   /note="Apolipoprotein C-I, acidic form"
FT                   /id="PRO_5003509369"
FT   CHAIN           27..81
FT                   /note="Truncated apolipoprotein C-I, acidic form"
FT                   /evidence="ECO:0000250|UniProtKB:P86336"
FT                   /id="PRO_0000436810"
SQ   SEQUENCE   81 AA;  9181 MW;  1DD15D2F2606384C CRC64;
     MRLFLSLLVV VLSMVLKGPT PAQGVPDVSN PFDVLEEFGK TLEDNVGEFI NLITQSELPA
     KTRDWFSETF RKVKEKLRIN S