ID   ILEU_XENTR              Reviewed;         377 AA.
AC   Q5I0S8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Leukocyte elastase inhibitor;
DE   AltName: Full=Serpin B1;
GN   Name=serpinb1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the activity of the neutrophil proteases.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC088021; AAH88021.1; -; mRNA.
DR   RefSeq; NP_001011419.1; NM_001011419.1.
DR   RefSeq; XP_012820078.1; XM_012964624.2.
DR   AlphaFoldDB; Q5I0S8; -.
DR   SMR; Q5I0S8; -.
DR   STRING; 8364.ENSXETP00000001376; -.
DR   MEROPS; I04.006; -.
DR   PaxDb; Q5I0S8; -.
DR   Ensembl; ENSXETT00000001376; ENSXETP00000001376; ENSXETG00000000624.
DR   GeneID; 496899; -.
DR   KEGG; xtr:496899; -.
DR   CTD; 1992; -.
DR   Xenbase; XB-GENE-1217264; serpinb1.
DR   eggNOG; KOG2392; Eukaryota.
DR   HOGENOM; CLU_023330_0_2_1; -.
DR   InParanoid; Q5I0S8; -.
DR   OMA; RKNINAW; -.
DR   OrthoDB; 1124079at2759; -.
DR   TreeFam; TF352619; -.
DR   Reactome; R-XTR-6798695; Neutrophil degranulation.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000624; Expressed in mesonephros and 15 other tissues.
DR   ExpressionAtlas; Q5I0S8; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IBA:GO_Central.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR015557; Serpin_B1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   PANTHER; PTHR11461:SF180; PTHR11461:SF180; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Protease inhibitor; Reference proteome;
KW   Serine protease inhibitor.
FT   CHAIN           1..377
FT                   /note="Leukocyte elastase inhibitor"
FT                   /id="PRO_0000289125"
FT   SITE            344..345
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   377 AA;  42519 MW;  B72047C541516888 CRC64;
     MENLSSACTH FSFDLFRKIN ENNATGNVFF SPISISTALA MVLLGARGNT AQQISRILHF
     DAVKDLHSNF QTLNAEINKK NVSSYALNLA NRLFGEKSFK FLPDFLSSVK KQYNADLGTV
     DFISAAEDAR KEINTWVSEQ TKGKIPEVLS AGAVNSFTKL VLVNAIYFKG DWAKKFKAEH
     TKDMPFQLNK KEQKTVKMMY QMEKLPFNYI PEINCRVLEL PYVDYELSMV IVLPDNINDD
     TTGLQQLEKE LSLEKINEWT ENMMPIDVHV HLPKFKLEDS YKLKSQLAGM GMADLFEAGS
     ADLSGMSGSN DLYLSEVIHK SFVEVNEEGT EAAAASAGIA MMCLMREEEF NANHPFLFFI
     RHNATKSILF FGRYSSP