ID   APO1A_PANPA             Reviewed;          83 AA.
AC   P86336;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JAN-2014, sequence version 2.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Apolipoprotein C-I, acidic form {ECO:0000303|PubMed:20209111};
DE            Short=Apo-CIA;
DE            Short=ApoC-IA;
DE   AltName: Full=Apolipoprotein C1A;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein C-I, acidic form;
DE              Short=Apo-CIA';
DE              Short=ApoC-IA';
DE   Flags: Precursor;
GN   Name=APOC1A; Synonyms=APOC1A';
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2]
RP   PROTEIN SEQUENCE OF 29-83, AND MASS SPECTROMETRY.
RX   PubMed=20209111; DOI=10.1016/j.cbd.2009.12.003;
RA   Puppione D.L., Ryan C.M., Bassilian S., Souda P., Xiao X., Ryder O.A.,
RA   Whitelegge J.P.;
RT   "Detection of two distinct forms of apoC-I in great apes.";
RL   Comp. Biochem. Physiol. 5D:73-79(2010).
RN   [3]
RP   IDENTIFICATION.
RA   Puppione D.L.;
RL   Unpublished observations (NOV-2013).
RN   [4]
RP   REVIEW.
RX   PubMed=28757862; DOI=10.1007/s11515-013-1278-7;
RA   Puppione D., Whitelegge J.P.;
RT   "Proteogenomic Review of the Changes in Primate apoC-I during Evolution.";
RL   Front. Biol. 8:533-548(2013).
RN   [5]
RP   GENE DUPLICATION.
RX   PubMed=25160599; DOI=10.1016/j.cbd.2014.08.001;
RA   Puppione D.L.;
RT   "Higher primates, but not New World monkeys, have a duplicate set of
RT   enhancers flanking their apoC-I genes.";
RL   Comp. Biochem. Physiol. 11:45-48(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC   -!- MASS SPECTROMETRY: [Truncated apolipoprotein C-I, acidic form]:
CC       Mass=6548.0; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:20209111};
CC   -!- MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and
CC       basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and
CC       perhaps also in baboons and macaques. The two genes for ApoC-I arose
CC       through a duplication process that occurred after the divergence of New
CC       World monkeys from the human lineage. In human, the acidic form has
CC       become a pseudogene sometime between the divergence of bonobos and
CC       chimpanzees from the human lineage and the appearance of the
CC       Denisovans. Pseudogenization resulted when the codon for the
CC       penultimate amino acid in the signal sequence was changed to a stop
CC       codon. {ECO:0000303|PubMed:25160599}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJFE01059483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P86336; -.
DR   SMR; P86336; -.
DR   STRING; 9597.XP_008969011.1; -.
DR   eggNOG; ENOG502SEU4; Eukaryota.
DR   Proteomes; UP000240080; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   Gene3D; 4.10.260.30; -; 1.
DR   InterPro; IPR043081; ApoC-1_sf.
DR   InterPro; IPR006781; ApoC-I.
DR   PANTHER; PTHR16565; PTHR16565; 1.
DR   Pfam; PF04691; ApoC-I; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Lipid transport; Reference proteome; Secreted;
KW   Signal; Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..83
FT                   /note="Apolipoprotein C-I, acidic form"
FT                   /id="PRO_0000424960"
FT   CHAIN           29..83
FT                   /note="Truncated apolipoprotein C-I, acidic form"
FT                   /evidence="ECO:0000269|PubMed:20209111"
FT                   /id="PRO_0000383668"
SQ   SEQUENCE   83 AA;  9417 MW;  9BC24B56BAA857E9 CRC64;
     MRLFLSLPVL VVVLSIVLEG PAPAQGAPEV SNPFDGLEEL GKTLEDNTRE FINRITQSEL
     PAKMWDWFSE TFRKVKEKLK IDS