APO1A_PANTR
ID APO1A_PANTR Reviewed; 83 AA.
AC P0CE37;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Apolipoprotein C-I, acidic form;
DE Short=Apo-CIA;
DE Short=ApoC-IA;
DE AltName: Full=Apolipoprotein C1A;
DE Contains:
DE RecName: Full=Truncated apolipoprotein C-I, acidic form;
DE Short=Apo-CIA';
DE Short=ApoC-IA';
DE Flags: Precursor;
GN Name=APOC1A;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2]
RP IDENTIFICATION, AND MASS SPECTROMETRY.
RX PubMed=20209111; DOI=10.1016/j.cbd.2009.12.003;
RA Puppione D.L., Ryan C.M., Bassilian S., Souda P., Xiao X., Ryder O.A.,
RA Whitelegge J.P.;
RT "Detection of two distinct forms of apoC-I in great apes.";
RL Comp. Biochem. Physiol. 5D:73-79(2010).
RN [3]
RP REVIEW.
RX PubMed=28757862; DOI=10.1007/s11515-013-1278-7;
RA Puppione D., Whitelegge J.P.;
RT "Proteogenomic Review of the Changes in Primate apoC-I during Evolution.";
RL Front. Biol. 8:533-548(2013).
RN [4]
RP GENE DUPLICATION.
RX PubMed=25160599; DOI=10.1016/j.cbd.2014.08.001;
RA Puppione D.L.;
RT "Higher primates, but not New World monkeys, have a duplicate set of
RT enhancers flanking their apoC-I genes.";
RL Comp. Biochem. Physiol. 11:45-48(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC -!- MASS SPECTROMETRY: [Apolipoprotein C-I, acidic form]: Mass=6716.0;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:20209111};
CC -!- MASS SPECTROMETRY: [Truncated apolipoprotein C-I, acidic form]:
CC Mass=6548.0; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:20209111};
CC -!- MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and
CC basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and
CC perhaps also in baboons and macaques. The two genes for ApoC-I arose
CC through a duplication process that occurred after the divergence of New
CC World monkeys from the human lineage. In human, the acidic form has
CC become a pseudogene sometime between the divergence of bonobos and
CC chimpanzees from the human lineage and the appearance of the
CC Denisovans. Pseudogenization resulted when the codon for the
CC penultimate amino acid in the signal sequence was changed to a stop
CC codon. {ECO:0000303|PubMed:25160599}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}.
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DR AlphaFoldDB; P0CE37; -.
DR SMR; P0CE37; -.
DR STRING; 9598.ENSPTRP00000060923; -.
DR PaxDb; P0CE37; -.
DR eggNOG; ENOG502SEU4; Eukaryota.
DR HOGENOM; CLU_160094_1_0_1; -.
DR InParanoid; P0CE37; -.
DR TreeFam; TF330940; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR GO; GO:0004859; F:phospholipase inhibitor activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0032375; P:negative regulation of cholesterol transport; IBA:GO_Central.
DR GO; GO:0050995; P:negative regulation of lipid catabolic process; IBA:GO_Central.
DR GO; GO:0051005; P:negative regulation of lipoprotein lipase activity; IBA:GO_Central.
DR GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IBA:GO_Central.
DR GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR GO; GO:0034447; P:very-low-density lipoprotein particle clearance; IBA:GO_Central.
DR Gene3D; 4.10.260.30; -; 1.
DR InterPro; IPR043081; ApoC-1_sf.
DR InterPro; IPR006781; ApoC-I.
DR PANTHER; PTHR16565; PTHR16565; 1.
DR Pfam; PF04691; ApoC-I; 1.
PE 1: Evidence at protein level;
KW Lipid transport; Reference proteome; Secreted; Signal; Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..83
FT /note="Apolipoprotein C-I, acidic form"
FT /id="PRO_0000391834"
FT CHAIN 29..83
FT /note="Truncated apolipoprotein C-I, acidic form"
FT /evidence="ECO:0000250|UniProtKB:P86336"
FT /id="PRO_0000391835"
SQ SEQUENCE 83 AA; 9435 MW; 2FC24B507C68512F CRC64;
MRLFLSLPVL VVVLSMVLEG PAPAQGAPEV SNPFDGLEEL GKTLEDNTRE FINRITQSEL
PAKMWDWFSE TFRKVKEKLK IDS
