ID   ILG1_CAEEL              Reviewed;          91 AA.
AC   Q18060;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Probable insulin-like peptide gamma-type 1;
DE   AltName: Full=Ceinsulin-3;
DE   Contains:
DE     RecName: Full=B-chain-like peptide;
DE   Contains:
DE     RecName: Full=A-chain-like peptide;
DE   Flags: Precursor;
GN   Name=ins-11; ORFNames=C17C3.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kawano T.;
RT   "mRNA for a putative insulin-like peptide of Caenorhabditis elegans.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   SIMILARITY TO INSULIN.
RX   PubMed=9548970; DOI=10.1101/gr.8.4.348;
RA   Duret L., Guex N., Peitsch M.C., Bairoch A.;
RT   "New insulin-like proteins with atypical disulfide bond pattern
RT   characterized in Caenorhabditis elegans by comparative sequence analysis
RT   and homology modeling.";
RL   Genome Res. 8:348-353(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; AB032258; BAA84470.1; -; mRNA.
DR   EMBL; FO080581; CCD64836.1; -; Genomic_DNA.
DR   PIR; T37327; T37327.
DR   RefSeq; NP_495071.1; NM_062670.1.
DR   AlphaFoldDB; Q18060; -.
DR   SMR; Q18060; -.
DR   BioGRID; 39283; 1.
DR   IntAct; Q18060; 1.
DR   STRING; 6239.C17C3.4; -.
DR   PaxDb; Q18060; -.
DR   EnsemblMetazoa; C17C3.4.1; C17C3.4.1; WBGene00002094.
DR   GeneID; 173941; -.
DR   KEGG; cel:CELE_C17C3.4; -.
DR   UCSC; C17C3.4; c. elegans.
DR   CTD; 173941; -.
DR   WormBase; C17C3.4; CE04024; WBGene00002094; ins-11.
DR   eggNOG; ENOG502TJ7G; Eukaryota.
DR   GeneTree; ENSGT00970000198336; -.
DR   HOGENOM; CLU_187880_0_0_1; -.
DR   InParanoid; Q18060; -.
DR   OMA; RCCKENC; -.
DR   OrthoDB; 1858664at2759; -.
DR   PhylomeDB; Q18060; -.
DR   PRO; PR:Q18060; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00002094; Expressed in larva and 3 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..91
FT                   /note="Probable insulin-like peptide gamma-type 1"
FT                   /id="PRO_0000016226"
FT   PEPTIDE         34..58
FT                   /note="B-chain-like peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016227"
FT   PEPTIDE         61..91
FT                   /note="A-chain-like peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016228"
FT   DISULFID        37..66
FT                   /evidence="ECO:0000255"
FT   DISULFID        49..79
FT                   /evidence="ECO:0000255"
FT   DISULFID        65..70
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   91 AA;  10173 MW;  22BF958BF759F254 CRC64;
     MSSYRQTLFI LIILIVIILF VNEGQGAPHH DKRHTACVLK IFKALNVMCN HEGDADVLRR
     TASDCCRESC SLTEMLASCT LTSSEESTRD I