ILRUN_MOUSE
ID ILRUN_MOUSE Reviewed; 291 AA.
AC Q3TT38; A2RT11;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Protein ILRUN;
GN Name=Ilrun {ECO:0000312|MGI:MGI:106281}; Synonyms=D17Wsu92e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Negative regulator of innate antiviral response. Blocks IRF3-
CC dependent cytokine production such as IFNA, IFNB and TNF. Interacts
CC with IRF3 and inhibits IRF3 recruitment to type I IFN promoter
CC sequences while also reducing nuclear levels of the coactivators EP300
CC and CREBBP. {ECO:0000250|UniProtKB:Q9H6K1}.
CC -!- SUBUNIT: Interacts with IRF3; the interaction inhibits IRF3 binding to
CC its DNA consensus sequence. {ECO:0000250|UniProtKB:Q9H6K1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H6K1}. Nucleus
CC {ECO:0000250|UniProtKB:Q9H6K1}.
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DR EMBL; AK161603; BAE36487.1; -; mRNA.
DR EMBL; AC126040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC131799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT009677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466606; EDL22550.1; -; Genomic_DNA.
DR EMBL; BC132324; AAI32325.1; -; mRNA.
DR EMBL; BC132326; AAI32327.1; -; mRNA.
DR EMBL; BC145403; AAI45404.1; -; mRNA.
DR CCDS; CCDS28569.1; -.
DR RefSeq; NP_001028451.2; NM_001033279.3.
DR RefSeq; NP_001258440.1; NM_001271511.1.
DR AlphaFoldDB; Q3TT38; -.
DR SMR; Q3TT38; -.
DR STRING; 10090.ENSMUSP00000110513; -.
DR iPTMnet; Q3TT38; -.
DR PhosphoSitePlus; Q3TT38; -.
DR EPD; Q3TT38; -.
DR jPOST; Q3TT38; -.
DR MaxQB; Q3TT38; -.
DR PaxDb; Q3TT38; -.
DR PRIDE; Q3TT38; -.
DR ProteomicsDB; 281647; -.
DR Antibodypedia; 49290; 68 antibodies from 15 providers.
DR Ensembl; ENSMUST00000114863; ENSMUSP00000110513; ENSMUSG00000056692.
DR GeneID; 224647; -.
DR KEGG; mmu:224647; -.
DR UCSC; uc008bpq.2; mouse.
DR CTD; 64771; -.
DR MGI; MGI:106281; Ilrun.
DR VEuPathDB; HostDB:ENSMUSG00000056692; -.
DR eggNOG; KOG4351; Eukaryota.
DR GeneTree; ENSGT00490000043415; -.
DR HOGENOM; CLU_076188_1_0_1; -.
DR InParanoid; Q3TT38; -.
DR OMA; FSAPCMS; -.
DR OrthoDB; 1359706at2759; -.
DR TreeFam; TF105872; -.
DR BioGRID-ORCS; 224647; 3 hits in 71 CRISPR screens.
DR ChiTaRS; D17Wsu92e; mouse.
DR PRO; PR:Q3TT38; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q3TT38; protein.
DR Bgee; ENSMUSG00000056692; Expressed in hindlimb stylopod muscle and 246 other tissues.
DR ExpressionAtlas; Q3TT38; baseline and differential.
DR Genevisible; Q3TT38; MM.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR GO; GO:0050687; P:negative regulation of defense response to virus; ISS:UniProtKB.
DR GO; GO:0043392; P:negative regulation of DNA binding; ISS:UniProtKB.
DR GO; GO:1900181; P:negative regulation of protein localization to nucleus; ISS:UniProtKB.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:UniProtKB.
DR GO; GO:0032480; P:negative regulation of type I interferon production; ISS:UniProtKB.
DR CDD; cd14947; NBR1_like; 1.
DR CDD; cd14349; UBA_CF106; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR039517; C6orf106_UBA-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032350; N_BRCA1_central.
DR InterPro; IPR009060; UBA-like_sf.
DR Pfam; PF16158; N_BRCA1_IG; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Immunity; Innate immunity; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..291
FT /note="Protein ILRUN"
FT /id="PRO_0000223319"
FT REGION 199..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6K1"
FT MOD_RES 222
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6K1"
FT MOD_RES 265
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6K1"
FT CONFLICT 111
FT /note="P -> T (in Ref. 1; BAE36487)"
FT /evidence="ECO:0000305"
FT CONFLICT 149
FT /note="P -> L (in Ref. 1; BAE36487)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="A -> D (in Ref. 1; BAE36487)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="G -> E (in Ref. 1; BAE36487)"
FT /evidence="ECO:0000305"
FT CONFLICT 204
FT /note="R -> S (in Ref. 1; BAE36487)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 291 AA; 32082 MW; E4F6C83587584EA5 CRC64;
MEGMDVDLDP ELMQKFSCLG TTDKDVLISE FQRLLGFQLN PAGCAFFLDM TNWNLQAAIG
AYYDFESPNI SVPSMSFVED VTIGEGESIP PDTQFIKTWR IQNSGAEAWP PGVCLKYVGG
DQFGHVNMVM VRSLEPQEIA DVSVQMCSPS RAGMYQGQWR MCTATGLYYG DVIWVILSVE
VGGLLGVTQQ LSSFETEFNT QPHRKVEGNF NPFASPQKNR QSDENNLTDP GGSEFDSISK
NTWAPVPEQS EQDQDRLSQS SVNLSPSSPA NNLSVVTYSK GLHGPYPFGQ S
