ID   APO1B_PONAB             Reviewed;          65 AA.
AC   P0CE40;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Apolipoprotein C-I, basic form;
DE            Short=Apo-CIB;
DE            Short=ApoC-IB;
DE   AltName: Full=Apolipoprotein C1B;
DE   Contains:
DE     RecName: Full=Cholesteryl ester transfer inhibitor protein;
DE              Short=CETIP;
DE   Flags: Precursor;
GN   Name=APOC1B;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=20209111; DOI=10.1016/j.cbd.2009.12.003;
RA   Puppione D.L., Ryan C.M., Bassilian S., Souda P., Xiao X., Ryder O.A.,
RA   Whitelegge J.P.;
RT   "Detection of two distinct forms of apoC-I in great apes.";
RL   Comp. Biochem. Physiol. 5D:73-79(2010).
RN   [3]
RP   REVIEW.
RX   PubMed=28757862; DOI=10.1007/s11515-013-1278-7;
RA   Puppione D., Whitelegge J.P.;
RT   "Proteogenomic Review of the Changes in Primate apoC-I during Evolution.";
RL   Front. Biol. 8:533-548(2013).
RN   [4]
RP   GENE DUPLICATION.
RX   PubMed=25160599; DOI=10.1016/j.cbd.2014.08.001;
RA   Puppione D.L.;
RT   "Higher primates, but not New World monkeys, have a duplicate set of
RT   enhancers flanking their apoC-I genes.";
RL   Comp. Biochem. Physiol. 11:45-48(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC   -!- MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and
CC       basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and
CC       perhaps also in baboons and macaques. The two genes for ApoC-I arose
CC       through a duplication process that occurred after the divergence of New
CC       World monkeys from the human lineage. In human, the acidic form has
CC       become a pseudogene sometime between the divergence of bonobos and
CC       chimpanzees from the human lineage and the appearance of the
CC       Denisovans. Pseudogenization resulted when the codon for the
CC       penultimate amino acid in the signal sequence was changed to a stop
CC       codon. {ECO:0000303|PubMed:25160599}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CE40; -.
DR   SMR; P0CE40; -.
DR   STRING; 9601.ENSPPYP00000011299; -.
DR   eggNOG; ENOG502SEU4; Eukaryota.
DR   HOGENOM; CLU_160094_1_0_1; -.
DR   InParanoid; P0CE40; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   Gene3D; 4.10.260.30; -; 1.
DR   InterPro; IPR043081; ApoC-1_sf.
DR   InterPro; IPR006781; ApoC-I.
DR   PANTHER; PTHR16565; PTHR16565; 1.
DR   Pfam; PF04691; ApoC-I; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Secreted; Signal; Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..65
FT                   /note="Apolipoprotein C-I, basic form"
FT                   /id="PRO_0000391840"
FT   CHAIN           29..65
FT                   /note="Cholesteryl ester transfer inhibitor protein"
FT                   /evidence="ECO:0000250|UniProtKB:P34929"
FT                   /id="PRO_0000391841"
SQ   SEQUENCE   65 AA;  7078 MW;  260E1BE8BDDBDF37 CRC64;
     MRLFLSLPVL VVVLSMVLEG PAPAQGAPDV SSALDKLKEF GNTLEDKARE VINRIKQSEL
     SAKTR