APO1_ORYSJ
ID APO1_ORYSJ Reviewed; 429 AA.
AC Q655Y0;
DT 03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Protein ABERRANT PANICLE ORGANIZATION 1 {ECO:0000303|PubMed:17666027, ECO:0000303|Ref.5};
DE AltName: Full=F-box protein 0393 {ECO:0000303|PubMed:21297981};
DE Short=Os_F0393 {ECO:0000303|PubMed:21297981};
DE AltName: Full=F-box protein 321 {ECO:0000303|PubMed:18775973};
DE Short=OsFbox321 {ECO:0000303|PubMed:18775973};
DE AltName: Full=Protein PRIMARY BRANCH NUMBER ON CHROMOSOME 6 {ECO:0000303|PubMed:20151298};
DE AltName: Full=Protein STRONG CULM 2 {ECO:0000303|PubMed:21119645};
GN Name=APO1 {ECO:0000303|PubMed:17666027, ECO:0000303|Ref.5};
GN Synonyms=F0393 {ECO:0000303|PubMed:21297981},
GN FBOX321 {ECO:0000303|PubMed:18775973}, PBN6 {ECO:0000303|PubMed:20151298},
GN SCM2 {ECO:0000303|PubMed:21119645};
GN OrderedLocusNames=Os06g0665400 {ECO:0000312|EMBL:BAS99029.1},
GN LOC_Os06g45460 {ECO:0000305};
GN ORFNames=OSNPB_060665400 {ECO:0000312|EMBL:BAS99029.1},
GN P0473H04.19 {ECO:0000312|EMBL:BAD45387.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Nipponbare;
RX PubMed=17666027; DOI=10.1111/j.1365-313x.2007.03200.x;
RA Ikeda K., Ito M., Nagasawa N., Kyozuka J., Nagato Y.;
RT "Rice ABERRANT PANICLE ORGANIZATION 1, encoding an F-box protein, regulates
RT meristem fate.";
RL Plant J. 51:1030-1040(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Kinmaze, and cv. Taichung 65;
RA Ikeda K., Nagasawa N., Nagato Y.;
RT "ABERRANT PANICLE ORGANIZATION 1 gene regulates meristem identity in
RT reproductive phase.";
RL Rice Genet. Newsl. 17:31-34(2000).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Kinmaze, and cv. Taichung 65;
RA Ikeda K., Nagasawa N., Nagato Y.;
RT "ABERRANT PANICLE ORGANIZATION 1 gene regulates the meristem organization
RT in rice.";
RL Rice Genet. Newsl. 19:42-45(2002).
RN [7]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Kinmaze, and cv. Taichung 65;
RX PubMed=15950602; DOI=10.1016/j.ydbio.2005.03.016;
RA Ikeda K., Nagasawa N., Nagato Y.;
RT "ABERRANT PANICLE ORGANIZATION 1 temporally regulates meristem identity in
RT rice.";
RL Dev. Biol. 282:349-360(2005).
RN [8]
RP TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=17293439; DOI=10.1104/pp.106.091900;
RA Jain M., Nijhawan A., Arora R., Agarwal P., Ray S., Sharma P., Kapoor S.,
RA Tyagi A.K., Khurana J.P.;
RT "F-box proteins in rice. Genome-wide analysis, classification, temporal and
RT spatial gene expression during panicle and seed development, and regulation
RT by light and abiotic stress.";
RL Plant Physiol. 143:1467-1483(2007).
RN [9]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18775973; DOI=10.1104/pp.108.121921;
RA Yang X., Kalluri U.C., Jawdy S., Gunter L.E., Yin T., Tschaplinski T.J.,
RA Weston D.J., Ranjan P., Tuskan G.A.;
RT "The F-box gene family is expanded in herbaceous annual plants relative to
RT woody perennial plants.";
RL Plant Physiol. 148:1189-1200(2008).
RN [10]
RP FUNCTION.
RX PubMed=19386809; DOI=10.1104/pp.109.136739;
RA Ikeda-Kawakatsu K., Yasuno N., Oikawa T., Iida S., Nagato Y., Maekawa M.,
RA Kyozuka J.;
RT "Expression level of ABERRANT PANICLE ORGANIZATION1 determines rice
RT inflorescence form through control of cell proliferation in the meristem.";
RL Plant Physiol. 150:736-747(2009).
RN [11]
RP GENE FAMILY.
RX PubMed=19126682; DOI=10.1073/pnas.0812043106;
RA Xu G., Ma H., Nei M., Kong H.;
RT "Evolution of F-box genes in plants: different modes of sequence divergence
RT and their relationships with functional diversification.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:835-840(2009).
RN [12]
RP FUNCTION.
RC STRAIN=cv. Koshihikari, and cv. Sasanishiki;
RX PubMed=21119645; DOI=10.1038/ncomms1132;
RA Ookawa T., Hobo T., Yano M., Murata K., Ando T., Miura H., Asano K.,
RA Ochiai Y., Ikeda M., Nishitani R., Ebitani T., Ozaki H., Angeles E.R.,
RA Hirasawa T., Matsuoka M.;
RT "New approach for rice improvement using a pleiotropic QTL gene for lodging
RT resistance and yield.";
RL Nat. Commun. 1:132-132(2010).
RN [13]
RP FUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF SER-15; ILE-39; ARG-226;
RP ARG-295 AND 315-GLY--GLY-317, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Sasanishiki;
RX PubMed=20151298; DOI=10.1007/s00122-009-1218-8;
RA Terao T., Nagata K., Morino K., Hirose T.;
RT "A gene controlling the number of primary rachis branches also controls the
RT vascular bundle formation and hence is responsible to increase the harvest
RT index and grain yield in rice.";
RL Theor. Appl. Genet. 120:875-893(2010).
RN [14]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21297981; DOI=10.1371/journal.pone.0016219;
RA Hua Z., Zou C., Shiu S.-H., Vierstra R.D.;
RT "Phylogenetic comparison of F-Box (FBX) gene superfamily within the plant
RT kingdom reveals divergent evolutionary histories indicative of genomic
RT drift.";
RL PLoS ONE 6:E16219-E16219(2011).
RN [15]
RP REVIEW ON QTL.
RX PubMed=21429786; DOI=10.1016/j.tplants.2011.02.009;
RA Miura K., Ashikari M., Matsuoka M.;
RT "The role of QTLs in the breeding of high-yielding rice.";
RL Trends Plant Sci. 16:319-326(2011).
RN [16]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH FL/APO2.
RX PubMed=21910771; DOI=10.1111/j.1365-313x.2011.04781.x;
RA Ikeda-Kawakatsu K., Maekawa M., Izawa T., Itoh J.-I., Nagato Y.;
RT "ABERRANT PANICLE ORGANIZATION 2/RFL, the rice ortholog of Arabidopsis
RT LEAFY, suppresses the transition from inflorescence meristem to floral
RT meristem through interaction with APO1.";
RL Plant J. 69:168-180(2012).
RN [17]
RP REVIEW ON QTL.
RX PubMed=23466256; DOI=10.1016/j.pbi.2013.02.002;
RA Ikeda M., Miura K., Aya K., Kitano H., Matsuoka M.;
RT "Genes offering the potential for designing yield-related traits in rice.";
RL Curr. Opin. Plant Biol. 16:213-220(2013).
RN [18]
RP REVIEW ON PANICLE BRANCHING GENES.
RX PubMed=24345551; DOI=10.1016/j.gene.2013.11.058;
RA Liang W.H., Shang F., Lin Q.T., Lou C., Zhang J.;
RT "Tillering and panicle branching genes in rice.";
RL Gene 537:1-5(2014).
RN [19]
RP FUNCTION.
RX PubMed=25381289; DOI=10.1093/mp/ssu131;
RA Yano K., Ookawa T., Aya K., Ochiai Y., Hirasawa T., Ebitani T.,
RA Takarada T., Yano M., Yamamoto T., Fukuoka S., Wu J., Ando T.,
RA Ordonio R.L., Hirano K., Matsuoka M.;
RT "Isolation of a novel lodging resistance QTL gene involved in strigolactone
RT signaling and its pyramiding with a QTL gene involved in another
RT mechanism.";
RL Mol. Plant 0:0-0(2014).
RN [20]
RP FUNCTION, AND INDUCTION BY OZONE.
RC STRAIN=cv. Sasanishiki;
RX PubMed=25923431; DOI=10.1371/journal.pone.0123308;
RA Tsukahara K., Sawada H., Kohno Y., Matsuura T., Mori I.C., Terao T.,
RA Ioki M., Tamaoki M.;
RT "Ozone-induced rice grain yield loss is triggered via a change in panicle
RT morphology that is controlled by ABERRANT PANICLE ORGANIZATION 1 gene.";
RL PLoS ONE 10:E0123308-E0123308(2015).
RN [21]
RP REVIEW.
RX PubMed=26987543; DOI=10.1186/s12284-016-0084-7;
RA Kim S.R., Ramos J., Ashikari M., Virk P.S., Torres E.A., Nissila E.,
RA Hechanova S.L., Mauleon R., Jena K.K.;
RT "Development and validation of allele-specific SNP/indel markers for eight
RT yield-enhancing genes using whole-genome sequencing strategy to increase
RT yield potential of rice, Oryza sativa L.";
RL Rice 9:12-12(2016).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins (By similarity). Together
CC with FL/APO2, involved in the temporal regulation of meristem identity
CC during both vegetative and reproductive developments in an APO2-
CC dependent manner (PubMed:17666027, Ref.5, Ref.6, PubMed:15950602,
CC PubMed:19386809, PubMed:21910771). Promotes spikelet formation by
CC suppressing the precocious conversion of inflorescence meristems to
CC spikelet meristems, probably via a positive regulation of class-C
CC floral homeotic genes, but not of class-B genes, and through the
CC control of cell proliferation in meristems (PubMed:17666027, Ref.6,
CC PubMed:19386809, PubMed:21119645). Mediates culm development and
CC strength/diameter enhancement at internodes (PubMed:21119645,
CC PubMed:25381289). Required for the regulation of the plastochron,
CC floral organ identity, and floral determinacy (PubMed:17666027, Ref.6,
CC PubMed:15950602, PubMed:19386809). Controls the number of primary
CC rachis branches (PRBs) (PubMed:20151298). May trigger the formation of
CC vascular bundle systems which, consequently, promote carbohydrate
CC translocation to panicles (PubMed:20151298). Involved in ozone-induced
CC grain yield regulation (PubMed:25923431).
CC {ECO:0000250|UniProtKB:Q8LEA8, ECO:0000269|PubMed:15950602,
CC ECO:0000269|PubMed:17666027, ECO:0000269|PubMed:19386809,
CC ECO:0000269|PubMed:20151298, ECO:0000269|PubMed:21119645,
CC ECO:0000269|PubMed:21910771, ECO:0000269|PubMed:25381289,
CC ECO:0000269|PubMed:25923431, ECO:0000269|Ref.5, ECO:0000269|Ref.6}.
CC -!- PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
CC -!- SUBUNIT: Part of a putative SCF (ASK/Cullin/F-box) ubiquitin ligase
CC complex (By similarity). Interacts with FL/APO2 (PubMed:21910771).
CC {ECO:0000250|UniProtKB:Q39090, ECO:0000269|PubMed:21910771}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in apical meristems and the lateral organ
CC primordia throughout development (PubMed:17666027). Expressed in
CC seedlings, roots, leaves, shoot apical meristem (SAM), developing
CC panicles, and, at lower levels, in developing seeds (PubMed:17293439,
CC PubMed:20151298). {ECO:0000269|PubMed:17293439,
CC ECO:0000269|PubMed:17666027, ECO:0000269|PubMed:20151298}.
CC -!- DEVELOPMENTAL STAGE: Present in the developing vascular bundle systems
CC (PubMed:20151298). In the vegetative phase, expressed in shoot apical
CC meristems (SAM) and leaf primordia (P1-P4 stage) (PubMed:17666027). In
CC the reproductive phase, first observed in the outer several cell layers
CC of the rachis meristem and primary branch meristems (PubMed:17666027,
CC PubMed:20151298). Confined to panicles primodia and young panicles,
CC particularly in the developing rachis branches (PubMed:20151298).
CC Accumulates later in the primary and secondary branch meristems, and in
CC the spikelet and floral meristems (PubMed:17666027). Also expressed in
CC lateral organs of spikelet and floral meristems, such as glumes,
CC lodicules, stamens and carpel, and in the ovule primordium
CC (PubMed:17666027). {ECO:0000269|PubMed:17666027,
CC ECO:0000269|PubMed:20151298}.
CC -!- INDUCTION: Induced by ozone. {ECO:0000269|PubMed:25923431}.
CC -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Reduced expression of class-C genes (Ref.6,
CC PubMed:15950602). Several abnormal phenotypes in the vegetative and
CC reproductive phases including accelerated leaves growth, aberrant
CC panicle distichous phyllotaxy organization and disturbed floral organ
CC identity (PubMed:17666027, Ref.5, Ref.6, PubMed:15950602,
CC PubMed:21910771). Aberrant conversion of rachis meristem to a spikelet
CC meristem after producing several primary branch primordia
CC (PubMed:17666027, Ref.5, Ref.6, PubMed:15950602). In flowers, frequent
CC replacement of stamens with lodicules (petals), and indeterminate
CC production of carpels (PubMed:17666027, Ref.6, PubMed:15950602).
CC Precocious formation of spikelet meristems and prolonged formation of
CC lodicules and carpels (PubMed:17666027, Ref.6, PubMed:15950602).
CC Reduced number of primary rachis branches (PRBs) and of the number of
CC grains per panicle, thus leading to reduced grain yield
CC (PubMed:20151298). {ECO:0000269|PubMed:15950602,
CC ECO:0000269|PubMed:17666027, ECO:0000269|PubMed:20151298,
CC ECO:0000269|PubMed:21910771, ECO:0000269|Ref.5, ECO:0000269|Ref.6}.
CC -!- MISCELLANEOUS: Ozone has various impact on different cultivars;
CC O.sativa subsp. japonica cv. Sasanishiki exhibits ozone-induced leaf
CC injury, but no grain yield loss, and, by contrast, O.sativa subsp.
CC indica cv. Habataki has grain yield loss with minimal leaf injury upon
CC ozone treatment. {ECO:0000269|PubMed:25923431}.
CC -!- MISCELLANEOUS: Plants harboring the PBN6 quantitative trait locus (QTL)
CC (e.g. HI1 allele in O.sativa subsp. indica cv. Habataki) exhibit bigger
CC peduncle diameter due to larger vascular bundles and an increased
CC number of primary rachis branches (PRBs) and of the number of grains
CC per panicle, thus leading to increased grain yield.
CC {ECO:0000269|PubMed:20151298}.
CC -!- MISCELLANEOUS: Plants harboring the SCM2 quantitative trait locus (QTL)
CC exhibit both an enhancement of culm strength at internodes and an
CC increased spikelet number leading to higher crop productivity and
CC better grain yield. {ECO:0000269|PubMed:21119645}.
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DR EMBL; AB292777; BAF75467.1; -; Genomic_DNA.
DR EMBL; AP003628; BAD45387.1; -; Genomic_DNA.
DR EMBL; AP014962; BAS99029.1; -; Genomic_DNA.
DR AlphaFoldDB; Q655Y0; -.
DR STRING; 4530.OS06T0665400-01; -.
DR PaxDb; Q655Y0; -.
DR PRIDE; Q655Y0; -.
DR EnsemblPlants; Os06t0665400-01; Os06t0665400-01; Os06g0665400.
DR Gramene; Os06t0665400-01; Os06t0665400-01; Os06g0665400.
DR eggNOG; ENOG502QR12; Eukaryota.
DR HOGENOM; CLU_038778_2_1_1; -.
DR InParanoid; Q655Y0; -.
DR OMA; ESFHIDA; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IMP:UniProtKB.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0010074; P:maintenance of meristem identity; IMP:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:UniProtKB.
DR GO; GO:0009909; P:regulation of flower development; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:1901342; P:regulation of vasculature development; IMP:UniProtKB.
DR GO; GO:0010193; P:response to ozone; IDA:UniProtKB.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF50965; SSF50965; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; Differentiation; Flowering; Kelch repeat;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Ubl conjugation pathway.
FT CHAIN 1..429
FT /note="Protein ABERRANT PANICLE ORGANIZATION 1"
FT /id="PRO_0000447616"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 25..71
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 229..277
FT /note="Kelch 1"
FT /evidence="ECO:0000255"
FT REPEAT 284..339
FT /note="Kelch 2"
FT /evidence="ECO:0000255"
FT REPEAT 350..397
FT /note="Kelch 3"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 15
FT /note="S->P: In PBN6; bigger peduncle diameter due to
FT larger vascular bundles, increased number of primary rachis
FT branches (PRBs) and of the number of grains per panicle,
FT thus leading to increased grain yield; when associated with
FT V-39, G-226, C-295 and 315-G--G-317 DEL."
FT /evidence="ECO:0000269|PubMed:20151298"
FT MUTAGEN 39
FT /note="I->V: In PBN6; bigger peduncle diameter due to
FT larger vascular bundles, increased number of primary rachis
FT branches (PRBs) and of the number of grains per panicle,
FT thus leading to increased grain yield; when associated with
FT P-15, G-226, C-295 and 315-G--G-317 DEL."
FT /evidence="ECO:0000269|PubMed:20151298"
FT MUTAGEN 226
FT /note="R->G: In PBN6; bigger peduncle diameter due to
FT larger vascular bundles, increased number of primary rachis
FT branches (PRBs) and of the number of grains per panicle,
FT thus leading to increased grain yield; when associated with
FT P-15, V-39, G-226, C-295 and 315-G--G-317 DEL."
FT /evidence="ECO:0000269|PubMed:20151298"
FT MUTAGEN 295
FT /note="R->C: In PBN6; bigger peduncle diameter due to
FT larger vascular bundles, increased number of primary rachis
FT branches (PRBs) and of the number of grains per panicle,
FT thus leading to increased grain yield; when associated with
FT P-15, V-39, G-226 and 315-G--G-317 DEL."
FT /evidence="ECO:0000269|PubMed:20151298"
FT MUTAGEN 315..317
FT /note="Missing: In PBN6; bigger peduncle diameter due to
FT larger vascular bundles, increased number of primary rachis
FT branches (PRBs) and of the number of grains per panicle,
FT thus leading to increased grain yield; when associated with
FT P-15, V-39, G-226 and C-295."
FT /evidence="ECO:0000269|PubMed:20151298"
SQ SEQUENCE 429 AA; 45022 MW; A71DFDCF3559246F CRC64;
MMNPRRLPPL PSSTSSASAA DDMDPRVWRR LPQPLVDRIL ACLPTPSFLR LRAACRRFYH
LLFSSPFLHS HLLLSPHLPF FAFVVPAAGH LLLLDPTATA SWSRLPLPLP PVAGGPAAFS
PAAASAGLLA FLSDASGHKT LLLANPITRL LAALPISPTP RLSPTVGLAA GPTSIIAVVA
GDDLVSPFAV KNISADTFVA DAASVPPSGF WAPSSLLPRL SSLDPRAGMA FASGRFYCMS
SSPFAVLVFD VAENVWSKVQ PPMRRFLRSP ALVELGGGRE GAARVALVSA VEKSRLSVPR
SVRLWTLRGG GGGGGGGAWT EVARMPPEVH AQFAAAEGGR GFECAAHGDY VVLAPRGPVA
QAPTSALVFD SRRDEWRWAP PCPYVVVAHH GGAGAAGFRV FAYEPRLATP AIGLLDATAP
VALHGMHDG
