ID   APO4_ARATH              Reviewed;         337 AA.
AC   Q9LSZ0; Q8GYN3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=APO protein 4, mitochondrial;
DE   Flags: Precursor;
GN   Name=APO4; OrderedLocusNames=At3g21740; ORFNames=MSD21.5;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
CC   -!- FUNCTION: May be involved in the stable assembly of several 4Fe-4S
CC       cluster-containing complexes of mitochondria. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- DOMAIN: The APO motifs may provide ligands for 4Fe-4S centers.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the APO family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00832}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB02836.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB025634; BAB02836.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE76547.1; -; Genomic_DNA.
DR   EMBL; AK117492; BAC42155.1; -; mRNA.
DR   RefSeq; NP_188811.2; NM_113069.3.
DR   AlphaFoldDB; Q9LSZ0; -.
DR   STRING; 3702.AT3G21740.1; -.
DR   PaxDb; Q9LSZ0; -.
DR   PRIDE; Q9LSZ0; -.
DR   ProteomicsDB; 244474; -.
DR   EnsemblPlants; AT3G21740.1; AT3G21740.1; AT3G21740.
DR   GeneID; 821728; -.
DR   Gramene; AT3G21740.1; AT3G21740.1; AT3G21740.
DR   KEGG; ath:AT3G21740; -.
DR   Araport; AT3G21740; -.
DR   TAIR; locus:2093069; AT3G21740.
DR   eggNOG; ENOG502QS7W; Eukaryota.
DR   HOGENOM; CLU_033199_1_0_1; -.
DR   InParanoid; Q9LSZ0; -.
DR   OMA; APSKYHC; -.
DR   OrthoDB; 720701at2759; -.
DR   PhylomeDB; Q9LSZ0; -.
DR   PRO; PR:Q9LSZ0; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LSZ0; baseline and differential.
DR   Genevisible; Q9LSZ0; AT.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   InterPro; IPR023342; APO_dom.
DR   Pfam; PF05634; APO_RNA-bind; 2.
DR   PROSITE; PS51499; APO; 2.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Repeat; Transit peptide.
FT   TRANSIT         1..20
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..337
FT                   /note="APO protein 4, mitochondrial"
FT                   /id="PRO_0000001933"
FT   DOMAIN          87..172
FT                   /note="APO 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00832"
FT   DOMAIN          228..313
FT                   /note="APO 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00832"
SQ   SEQUENCE   337 AA;  38544 MW;  ADD5A4854F29710F CRC64;
     MSNWRHKLWR KLSSFQRASY STTSSRNNKL KLDDLRKLRP MILKRIENRA KDYPVKEIVP
     VAEEILIARK NLISNIAALL KVFPVLTCKF CSEVFVGKEG HLIETCRSYI RRGNNRLHEW
     VPGSINDILV PVESYHLHNI SQGVIRHQER FDYDRVPAIL ELCCQAGAIH PEEILQYSEI
     HDNPQISEED IRSLPAGDLK YVGANALMAW EKVRAGVKKL LLVYPSKVCK RCKEVHVGPS
     GHKARLCGVF KYESWRGTHY WEKAGVNDLV PEKMVWHRRP QDPVVLVDEG RSYYGHAPAI
     VSLCSHTGAI VPVKYACKMK PQGLSFSFTN PVPNLET