ID   APOA1_ANAPL             Reviewed;         264 AA.
AC   O42296;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Apolipoprotein A-I;
DE            Short=Apo-AI;
DE            Short=ApoA-I;
DE   AltName: Full=Apolipoprotein A1;
DE   Contains:
DE     RecName: Full=Proapolipoprotein A-I;
DE              Short=ProapoA-I;
DE   Flags: Precursor;
GN   Name=APOA1;
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8839;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Pekin breed; TISSUE=Liver;
RA   Chen B., Lu X., Wang K., Xue H., Zeng W., Zhu D., Chi L.;
RT   "Cloning and sequencing of duck apolipoprotein AI cDNA.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in the reverse transport of cholesterol from
CC       tissues to the liver for excretion by promoting cholesterol efflux from
CC       tissues and by acting as a cofactor for the lecithin cholesterol
CC       acyltransferase (LCAT). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Major protein of plasma HDL, also found in
CC       chylomicrons.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U86131; AAB64381.1; -; mRNA.
DR   PIR; A61448; A61448.
DR   AlphaFoldDB; O42296; -.
DR   SMR; O42296; -.
DR   PRIDE; O42296; -.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   InterPro; IPR000074; ApoA_E.
DR   Pfam; PF01442; Apolipoprotein; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; HDL; Lipid metabolism; Lipid transport; Repeat;
KW   Secreted; Signal; Steroid metabolism; Sterol metabolism; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..264
FT                   /note="Proapolipoprotein A-I"
FT                   /id="PRO_0000425340"
FT   CHAIN           25..264
FT                   /note="Apolipoprotein A-I"
FT                   /id="PRO_0000001958"
FT   REPEAT          67..88
FT                   /note="1"
FT   REPEAT          89..110
FT                   /note="2"
FT   REPEAT          111..121
FT                   /note="3; half-length"
FT   REPEAT          122..143
FT                   /note="4"
FT   REPEAT          144..165
FT                   /note="5"
FT   REPEAT          166..187
FT                   /note="6"
FT   REPEAT          188..209
FT                   /note="7"
FT   REPEAT          210..231
FT                   /note="8"
FT   REPEAT          232..242
FT                   /note="9; half-length"
FT   REPEAT          243..264
FT                   /note="10"
FT   REGION          67..264
FT                   /note="10 X approximate tandem repeats"
SQ   SEQUENCE   264 AA;  30659 MW;  7546F4BAF2846900 CRC64;
     MRVVVVTLAL LFLTGTQARY FWQHDEPQAP LDRLRDLVDV YLETVKASGK DAIAQFEASA
     VGKQLDLKLA DNLDTLGAAA AKLREDMAPY YKEVREMWLK DTESLRAELT KDLEEVKEKI
     RPFLDQFSAK WTEELEQYRQ RLAPVAEELK ELTKQKVELM QQKLTPVAEE ARDRLRGHVE
     ELRKNLAPYS DELRQKLSQK LEEIREKGIP QAAEYQAKVV EQLSNLREKM TPLVQDFKER
     LTPYAENLKT RFISLLDELQ KTVA