ID   1104L_ASFB7             Reviewed;         124 AA.
AC   P18558;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Protein MGF 110-4L;
DE   Flags: Precursor;
GN   OrderedLocusNames=BA71V-011, BA71V-012; ORFNames=XP124L;
OS   African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10498;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2325202; DOI=10.1128/jvi.64.5.2064-2072.1990;
RA   Almendral J.M., Almazan F., Blasco R., Vinuela E.;
RT   "Multigene families in African swine fever virus: family 110.";
RL   J. Virol. 64:2064-2072(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11831707; DOI=10.1006/viro.1995.1149;
RA   Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C.,
RA   Rodriguez J.F., Vinuela E.;
RT   "Analysis of the complete nucleotide sequence of African swine fever
RT   virus.";
RL   Virology 208:249-278(1995).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=9499098; DOI=10.1128/jvi.72.3.2373-2387.1998;
RA   Rouiller I., Brookes S.M., Hyatt A.D., Windsor M., Wileman T.;
RT   "African swine fever virus is wrapped by the endoplasmic reticulum.";
RL   J. Virol. 72:2373-2387(1998).
RN   [4]
RP   SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=15016891; DOI=10.1128/jvi.78.7.3710-3721.2004;
RA   Netherton C., Rouiller I., Wileman T.;
RT   "The subcellular distribution of multigene family 110 proteins of African
RT   swine fever virus is determined by differences in C-terminal KDEL
RT   endoplasmic reticulum retention motifs.";
RL   J. Virol. 78:3710-3721(2004).
RN   [5]
RP   INDUCTION.
RX   PubMed=32075923; DOI=10.1128/jvi.00119-20;
RA   Cackett G., Matelska D., Sykora M., Portugal R., Malecki M., Baehler J.,
RA   Dixon L., Werner F.;
RT   "The African Swine Fever Virus Transcriptome.";
RL   J. Virol. 94:0-0(2020).
CC   -!- FUNCTION: Causes the redistribution of lumenal ER protein to an
CC       enlarged ERGIC compartment. {ECO:0000269|PubMed:15016891}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:9499098}. Host
CC       endoplasmic reticulum-Golgi intermediate compartment
CC       {ECO:0000269|PubMed:15016891, ECO:0000269|PubMed:9499098}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:32075923}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 110 family. {ECO:0000305}.
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DR   EMBL; M36467; AAA42686.1; -; Genomic_DNA.
DR   EMBL; U18466; AAA65245.1; -; Genomic_DNA.
DR   PIR; C43702; C43702.
DR   RefSeq; NP_042709.1; NC_001659.2.
DR   GeneID; 22220399; -.
DR   KEGG; vg:22220399; -.
DR   Proteomes; UP000000624; Genome.
DR   GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004848; ASFV_fam_110.
DR   Pfam; PF01639; v110; 1.
PE   2: Evidence at transcript level;
KW   Early protein; Glycoprotein; Reference proteome; Signal; Virion.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250|UniProtKB:A9JLI5"
FT   CHAIN           29..124
FT                   /note="Protein MGF 110-4L"
FT                   /id="PRO_0000036736"
FT   MOTIF           121..124
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000269|PubMed:15016891"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   124 AA;  14194 MW;  DD62EB6C7067D74B CRC64;
     MLVIFLGILG LLANQVLGLP TQAGGHLRST DNPPQEELGY WCTYMESCKF CWECAHGICK
     NKVNESMPLI IENSYLTSCE VSRWYNQCTY SEGNGHYHVM DCSNPVPHNR PHRLGRKIYE
     KEDL