APOA1_DANRE
ID APOA1_DANRE Reviewed; 262 AA.
AC O42363; Q5XJ38;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Apolipoprotein A-I;
DE Short=Apo-AI;
DE Short=ApoA-I;
DE AltName: Full=Apolipoprotein A1;
DE Contains:
DE RecName: Full=Proapolipoprotein A-I;
DE Short=ProapoA-I;
DE Flags: Precursor;
GN Name=apoa1; Synonyms=apoa; ORFNames=zgc:103718;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9238027; DOI=10.1073/pnas.94.16.8622;
RA Babin P.J., Thisse C., Durliat M., Andre M., Akimenko M.-A., Thisse B.;
RT "Both apolipoprotein E and A-I genes are present in a nonmammalian
RT vertebrate and are highly expressed during embryonic development.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:8622-8627(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INTERACTION WITH NAXE AND YJEFN3.
RX PubMed=23719382; DOI=10.1038/nature12166;
RA Fang L., Choi S.H., Baek J.S., Liu C., Almazan F., Ulrich F., Wiesner P.,
RA Taleb A., Deer E., Pattison J., Torres-Vazquez J., Li A.C., Miller Y.I.;
RT "Control of angiogenesis by AIBP-mediated cholesterol efflux.";
RL Nature 498:118-122(2013).
CC -!- FUNCTION: Participates in the reverse transport of cholesterol from
CC tissues to the liver for excretion by promoting cholesterol efflux from
CC tissues and by acting as a cofactor for the lecithin cholesterol
CC acyltransferase (LCAT). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer (By similarity). Interacts with NAXE and YJEFN3
CC (PubMed:23719382). {ECO:0000250|UniProtKB:G5BQH5,
CC ECO:0000269|PubMed:23719382}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- DEVELOPMENTAL STAGE: Highly expressed in the yolk syncytial layer
CC during embryonic (starting at the gastrula stage) and early larval
CC development, an extraembryonic structure implicated in embryonic and
CC larval nutrition. {ECO:0000269|PubMed:9238027}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH83473.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; Y13653; CAA74004.1; -; mRNA.
DR EMBL; BC083473; AAH83473.1; ALT_FRAME; mRNA.
DR RefSeq; NP_571203.1; NM_131128.1.
DR AlphaFoldDB; O42363; -.
DR SMR; O42363; -.
DR BioGRID; 78555; 1.
DR STRING; 7955.ENSDARP00000025613; -.
DR PaxDb; O42363; -.
DR PeptideAtlas; O42363; -.
DR PRIDE; O42363; -.
DR DNASU; 30355; -.
DR Ensembl; ENSDART00000012050; ENSDARP00000025613; ENSDARG00000012076.
DR Ensembl; ENSDART00000187198; ENSDARP00000155136; ENSDARG00000110395.
DR GeneID; 30355; -.
DR KEGG; dre:30355; -.
DR CTD; 30355; -.
DR ZFIN; ZDB-GENE-990415-14; apoa1a.
DR eggNOG; ENOG502S1XQ; Eukaryota.
DR GeneTree; ENSGT00950000182929; -.
DR HOGENOM; CLU_058447_0_0_1; -.
DR InParanoid; O42363; -.
DR OMA; LGCHART; -.
DR OrthoDB; 1553412at2759; -.
DR PhylomeDB; O42363; -.
DR TreeFam; TF334458; -.
DR Reactome; R-DRE-114608; Platelet degranulation.
DR Reactome; R-DRE-1369062; ABC transporters in lipid homeostasis.
DR Reactome; R-DRE-2168880; Scavenging of heme from plasma.
DR Reactome; R-DRE-3000471; Scavenging by Class B Receptors.
DR Reactome; R-DRE-3000480; Scavenging by Class A Receptors.
DR Reactome; R-DRE-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-DRE-8957275; Post-translational protein phosphorylation.
DR Reactome; R-DRE-8963888; Chylomicron assembly.
DR Reactome; R-DRE-8963896; HDL assembly.
DR Reactome; R-DRE-8964011; HDL clearance.
DR Reactome; R-DRE-8964058; HDL remodeling.
DR Reactome; R-DRE-9707616; Heme signaling.
DR Reactome; R-DRE-975634; Retinoid metabolism and transport.
DR PRO; PR:O42363; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000012076; Expressed in intestine and 19 other tissues.
DR GO; GO:0042627; C:chylomicron; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IDA:ZFIN.
DR GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0006695; P:cholesterol biosynthetic process; IBA:GO_Central.
DR GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central.
DR GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR GO; GO:0034380; P:high-density lipoprotein particle assembly; IBA:GO_Central.
DR GO; GO:0042157; P:lipoprotein metabolic process; IBA:GO_Central.
DR GO; GO:0033700; P:phospholipid efflux; IBA:GO_Central.
DR GO; GO:0010873; P:positive regulation of cholesterol esterification; IBA:GO_Central.
DR GO; GO:0046889; P:positive regulation of lipid biosynthetic process; IBA:GO_Central.
DR GO; GO:0043691; P:reverse cholesterol transport; IBA:GO_Central.
DR GO; GO:0070328; P:triglyceride homeostasis; IBA:GO_Central.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IBA:GO_Central.
DR InterPro; IPR000074; ApoA_E.
DR Pfam; PF01442; Apolipoprotein; 1.
PE 1: Evidence at protein level;
KW Cholesterol metabolism; HDL; Lipid metabolism; Lipid transport;
KW Reference proteome; Repeat; Secreted; Signal; Steroid metabolism;
KW Sterol metabolism; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..262
FT /note="Proapolipoprotein A-I"
FT /id="PRO_0000425343"
FT CHAIN 24..262
FT /note="Apolipoprotein A-I"
FT /id="PRO_0000001964"
FT REPEAT 64..85
FT /note="1"
FT REPEAT 87..107
FT /note="2"
FT REPEAT 108..118
FT /note="3; half-length"
FT REPEAT 119..140
FT /note="4"
FT REPEAT 141..162
FT /note="5"
FT REPEAT 163..184
FT /note="6"
FT REPEAT 185..206
FT /note="7"
FT REPEAT 207..228
FT /note="8"
FT REPEAT 229..239
FT /note="9; half-length"
FT REPEAT 240..262
FT /note="10"
FT REGION 32..63
FT /note="3 X approximate tandem repeats"
FT REGION 64..262
FT /note="10 X approximate tandem repeats"
FT CONFLICT 65
FT /note="Q -> L (in Ref. 2; AAH83473)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 262 AA; 30256 MW; BB839A0A815365B9 CRC64;
MKFVALALTL LLALGSQANL FQADAPTQLE HYKAAALVYL NQVKDQAEKA LDNLDGTDYE
QYKLQLSESL TKLQEYAQTT SQALTPYAET ISTQLMENTK QLRERVMTDV EDLRSKLEPH
RAELYTALQK HIDEYREKLE PVFQEYSALN RQNAEQLRAK LEPLMDDIRK AFESNIEETK
SKVVPMVEAV RTKLTERLED LRTMAAPYAE EYKEQLVKAV EEAREKIAPH TQDLQTRMEP
YMENVRTTFA QMYETIAKAI QA
