ID   4EBP3_MOUSE             Reviewed;         101 AA.
AC   Q80VV3; Q2TA53;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Eukaryotic translation initiation factor 4E-binding protein 3;
DE            Short=4E-BP3;
DE            Short=eIF4E-binding protein 3;
GN   Name=Eif4ebp3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Poulin F., Sonenberg N.;
RT   "Two overlapping reading frames in the second exon of the translational
RT   inhibitor 4E-BP3.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Repressor of translation initiation that regulates EIF4E
CC       activity by preventing its assembly into the eIF4F complex:
CC       hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds
CC       to EIF4E, leading to repress translation. In contrast,
CC       hyperphosphorylated form dissociates from EIF4E, allowing interaction
CC       between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
CC       {ECO:0000250|UniProtKB:Q13541}.
CC   -!- SUBUNIT: EIF4EBP3 interacts with EIF4E. {ECO:0000250|UniProtKB:O60516}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:O60516}.
CC   -!- SIMILARITY: Belongs to the eIF4E-binding protein family. {ECO:0000305}.
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DR   EMBL; AY226182; AAO73448.1; -; mRNA.
DR   EMBL; BC061242; AAH61242.1; -; mRNA.
DR   EMBL; BC111107; AAI11108.1; -; mRNA.
DR   CCDS; CCDS29155.1; -.
DR   RefSeq; NP_957708.1; NM_201256.4.
DR   AlphaFoldDB; Q80VV3; -.
DR   SMR; Q80VV3; -.
DR   STRING; 10090.ENSMUSP00000039298; -.
DR   iPTMnet; Q80VV3; -.
DR   PhosphoSitePlus; Q80VV3; -.
DR   MaxQB; Q80VV3; -.
DR   PaxDb; Q80VV3; -.
DR   PRIDE; Q80VV3; -.
DR   ProteomicsDB; 296419; -.
DR   Antibodypedia; 34915; 131 antibodies from 18 providers.
DR   DNASU; 108112; -.
DR   Ensembl; ENSMUST00000036765; ENSMUSP00000039298; ENSMUSG00000090264.
DR   GeneID; 108112; -.
DR   KEGG; mmu:108112; -.
DR   UCSC; uc008enx.2; mouse.
DR   CTD; 8637; -.
DR   MGI; MGI:1270847; Eif4ebp3.
DR   VEuPathDB; HostDB:ENSMUSG00000090264; -.
DR   eggNOG; ENOG502S03G; Eukaryota.
DR   GeneTree; ENSGT00940000163328; -.
DR   HOGENOM; CLU_111706_0_0_1; -.
DR   InParanoid; Q80VV3; -.
DR   OMA; YSTTPHG; -.
DR   OrthoDB; 1597535at2759; -.
DR   PhylomeDB; Q80VV3; -.
DR   TreeFam; TF101530; -.
DR   BioGRID-ORCS; 108112; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Eif4ebp3; mouse.
DR   PRO; PR:Q80VV3; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; Q80VV3; protein.
DR   Bgee; ENSMUSG00000090264; Expressed in ileum and 58 other tissues.
DR   Genevisible; Q80VV3; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008190; F:eukaryotic initiation factor 4E binding; IBA:GO_Central.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IBA:GO_Central.
DR   InterPro; IPR008606; EIF4EBP.
DR   Pfam; PF05456; eIF_4EBP; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Protein synthesis inhibitor; Reference proteome;
KW   Translation regulation.
FT   CHAIN           1..101
FT                   /note="Eukaryotic translation initiation factor 4E-binding
FT                   protein 3"
FT                   /id="PRO_0000190519"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           40..46
FT                   /note="YXXXXLphi motif"
FT                   /evidence="ECO:0000250|UniProtKB:P70445"
FT   MOTIF           97..101
FT                   /note="TOS motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q13541"
SQ   SEQUENCE   101 AA;  11019 MW;  78F82052696A9BD7 CRC64;
     MSSSTSCPIP GCRDQLPDGY STTPGGTLYA TTPGGTRIIY DRKFLLECKN SPIARTPPCC
     LPQIPGVTTL PAVPPSKLEL LKEQKQTEVE ITDDEQFEMD M