ID   4EBP_DICDI              Reviewed;         103 AA.
AC   Q54DU8; Q9NDN6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Eukaryotic translation initiation factor 4E-1A-binding protein homolog;
DE            Short=4E-BP;
GN   Name=febA; ORFNames=DDB_G0291990;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX4;
RX   PubMed=11406272; DOI=10.1016/s0167-4781(01)00219-6;
RA   Morio T., Yasukawa H., Urushihara H., Saito T., Ochiai H., Takeuchi I.,
RA   Maeda M., Tanaka Y.;
RT   "FebA: a gene for eukaryotic translation initiation factor 4E-binding
RT   protein (4E-BP) in Dictyostelium discoideum.";
RL   Biochim. Biophys. Acta 1519:65-69(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Regulates assembly of the eIF4F complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF4E-binding protein family. {ECO:0000305}.
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DR   EMBL; AB038152; BAB03511.1; -; mRNA.
DR   EMBL; AAFI02000187; EAL61351.1; -; Genomic_DNA.
DR   RefSeq; XP_629774.1; XM_629772.1.
DR   AlphaFoldDB; Q54DU8; -.
DR   STRING; 44689.DDB0191098; -.
DR   PaxDb; Q54DU8; -.
DR   EnsemblProtists; EAL61351; EAL61351; DDB_G0291990.
DR   GeneID; 8628450; -.
DR   KEGG; ddi:DDB_G0291990; -.
DR   dictyBase; DDB_G0291990; febA.
DR   eggNOG; ENOG502S44S; Eukaryota.
DR   HOGENOM; CLU_111706_0_0_1; -.
DR   InParanoid; Q54DU8; -.
DR   OMA; DPRNDIN; -.
DR   Reactome; R-DDI-166208; mTORC1-mediated signalling.
DR   Reactome; R-DDI-72662; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.
DR   PRO; PR:Q54DU8; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008190; F:eukaryotic initiation factor 4E binding; IBA:GO_Central.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IBA:GO_Central.
DR   InterPro; IPR008606; EIF4EBP.
DR   Pfam; PF05456; eIF_4EBP; 1.
PE   3: Inferred from homology;
KW   Protein synthesis inhibitor; Reference proteome; Translation regulation.
FT   CHAIN           1..103
FT                   /note="Eukaryotic translation initiation factor 4E-1A-
FT                   binding protein homolog"
FT                   /id="PRO_0000327670"
FT   REGION          49..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        101
FT                   /note="P -> T (in Ref. 1; BAB03511)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   103 AA;  11195 MW;  970CDD294F20AB61 CRC64;
     MSTTRAIPVS LKDRSDIDFS TSLGGTLYGT TPGGTKIVYD RNALLQYRNS PLSKTPPPQL
     AHITNTELNK KVEKSTTTPT TTTPPTTTAK PKPTNDDDIF PME