ID   APOA1_SALSA             Reviewed;         258 AA.
AC   P27007;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Apolipoprotein A-I;
DE            Short=Apo-AI;
DE            Short=ApoA-I;
DE   AltName: Full=Apolipoprotein A1;
DE   Contains:
DE     RecName: Full=Proapolipoprotein A-I;
DE              Short=ProapoA-I;
DE   Flags: Precursor;
GN   Name=apoa1;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=1916288; DOI=10.1016/0378-1119(91)90245-7;
RA   Powell R., Higgins D.G., Wolff J., Byrnes L., Stack M., Sharp P.M.,
RA   Gannon F.;
RT   "The salmon gene encoding apolipoprotein A-I: cDNA sequence, tissue
RT   expression and evolution.";
RL   Gene 104:155-161(1991).
CC   -!- FUNCTION: Participates in the reverse transport of cholesterol from
CC       tissues to the liver for excretion by promoting cholesterol efflux from
CC       tissues and by acting as a cofactor for the lecithin cholesterol
CC       acyltransferase (LCAT). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Major protein of plasma HDL, also found in
CC       chylomicrons. Expressed in liver, intestine and muscle.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC       {ECO:0000305}.
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DR   EMBL; X52237; CAA36482.1; -; mRNA.
DR   PIR; JH0472; JH0472.
DR   RefSeq; NP_001117135.1; NM_001123663.1.
DR   AlphaFoldDB; P27007; -.
DR   SMR; P27007; -.
DR   GeneID; 100136573; -.
DR   KEGG; sasa:100136573; -.
DR   Proteomes; UP000087266; Chromosome ssa20.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   InterPro; IPR000074; ApoA_E.
DR   Pfam; PF01442; Apolipoprotein; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; HDL; Lipid metabolism; Lipid transport;
KW   Reference proteome; Repeat; Secreted; Signal; Steroid metabolism;
KW   Sterol metabolism; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..258
FT                   /note="Proapolipoprotein A-I"
FT                   /id="PRO_0000425346"
FT   CHAIN           32..258
FT                   /note="Apolipoprotein A-I"
FT                   /id="PRO_0000001970"
FT   REPEAT          64..85
FT                   /note="1"
FT   REPEAT          86..106
FT                   /note="2"
FT   REPEAT          107..117
FT                   /note="3; half-length"
FT   REPEAT          118..139
FT                   /note="4"
FT   REPEAT          140..161
FT                   /note="5"
FT   REPEAT          162..183
FT                   /note="6"
FT   REPEAT          184..205
FT                   /note="7"
FT   REPEAT          206..227
FT                   /note="8"
FT   REPEAT          228..238
FT                   /note="9"
FT   REPEAT          239..258
FT                   /note="10"
FT   REGION          32..63
FT                   /note="3 X approximate tandem repeats"
FT   REGION          64..258
FT                   /note="10 X approximate tandem repeats"
FT   REGION          233..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   258 AA;  29448 MW;  44B6C7E82D8179F3 CRC64;
     MKFLVLALTI LLAAGTQAFP MQADAPSQLE HVKAALNMYI AQVKLTAQRS IDLLDDTEYK
     EYKMQLSQSL DNLQQFADST SKSWPPTPRS SAPSCDATAT VRAEVMKDVE DVRTQLEPKR
     AELTEVLNKH IDEYRKKLEP LIKQHIELRR TEMDAFRAKI DPVVEEMRAK VAVNVEETKT
     KLMPIVEIVR AKLTERLEEL RTLAAPYAEE YKEQMFKAVG EVREKVAPLS EDFKARWAPP
     PRRPSKSSWL STRPSARP