ID   APOA1_SALTR             Reviewed;         262 AA.
AC   Q91488;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Apolipoprotein A-I;
DE            Short=Apo-AI;
DE            Short=ApoA-I;
DE   AltName: Full=Apolipoprotein A1;
DE   Contains:
DE     RecName: Full=Proapolipoprotein A-I;
DE              Short=ProapoA-I;
DE   Flags: Precursor;
GN   Name=apoa1; Synonyms=apoai;
OS   Salmo trutta (Brown trout).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8032;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Drover V.A.B.;
RL   Thesis (1995), University of Illinois, United States.
CC   -!- FUNCTION: Participates in the reverse transport of cholesterol from
CC       tissues to the liver for excretion by promoting cholesterol efflux from
CC       tissues and by acting as a cofactor for the lecithin cholesterol
CC       acyltransferase (LCAT). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC       {ECO:0000305}.
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DR   EMBL; L49383; AAA88542.1; -; mRNA.
DR   AlphaFoldDB; Q91488; -.
DR   SMR; Q91488; -.
DR   Proteomes; UP000472277; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   InterPro; IPR000074; ApoA_E.
DR   Pfam; PF01442; Apolipoprotein; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; HDL; Lipid metabolism; Lipid transport;
KW   Reference proteome; Repeat; Secreted; Signal; Steroid metabolism;
KW   Sterol metabolism; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..262
FT                   /note="Proapolipoprotein A-I"
FT                   /id="PRO_0000425347"
FT   CHAIN           24..262
FT                   /note="Apolipoprotein A-I"
FT                   /id="PRO_0000001972"
FT   REPEAT          64..85
FT                   /note="1"
FT   REPEAT          87..107
FT                   /note="2"
FT   REPEAT          108..118
FT                   /note="3; half-length"
FT   REPEAT          119..140
FT                   /note="4"
FT   REPEAT          141..162
FT                   /note="5"
FT   REPEAT          163..184
FT                   /note="6"
FT   REPEAT          185..206
FT                   /note="7"
FT   REPEAT          207..228
FT                   /note="8"
FT   REPEAT          229..239
FT                   /note="9; half-length"
FT   REPEAT          240..262
FT                   /note="10"
FT   REGION          32..63
FT                   /note="3 X approximate tandem repeats"
FT   REGION          64..262
FT                   /note="10 X approximate tandem repeats"
SQ   SEQUENCE   262 AA;  29704 MW;  55644FA4A0E21836 CRC64;
     MKFLALALTI LLAAATQAVP MQADAPSQLE HVKVAMMEYM AQVKETGQRS IDLLDDTEFK
     EYKVQLSQSL DNLQQYAQTT SQSLAPYSEA FGAQLTDAAA AVRAEVMKDV EDVRTQLEPK
     RAELKEVLDK HIDEYRKKLE PLIKEIVEQR RTELEAFRVK MEPVVEEMRA KVSTNVEETK
     AKLMPIVETV RAKLTERLEE LRTLAAPYAE EYKEQMFKAV GEVREKVGPL TNDFKGQVGP
     AAEQAKEKLM DFYETISQAM KA