APOA1_SPAAU
ID APOA1_SPAAU Reviewed; 260 AA.
AC O42175;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Apolipoprotein A-I;
DE Short=Apo-AI;
DE Short=ApoA-I;
DE AltName: Full=Apolipoprotein A1;
DE Contains:
DE RecName: Full=Proapolipoprotein A-I;
DE Short=ProapoA-I;
DE Flags: Precursor;
GN Name=apoa1;
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=9804999; DOI=10.1016/s0167-4781(98)00171-7;
RA Llewellyn L., Ramsurn V.P., Wigham T., Sweeney G.E., Power D.M.;
RT "Cloning, characterisation and expression of the apolipoprotein A-I gene in
RT the sea bream (Sparus aurata).";
RL Biochim. Biophys. Acta 1442:399-404(1998).
CC -!- FUNCTION: Participates in the reverse transport of cholesterol from
CC tissues to the liver for excretion by promoting cholesterol efflux from
CC tissues and by acting as a cofactor for the lecithin cholesterol
CC acyltransferase (LCAT). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strong expression in liver with lower expression in
CC intestine.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000305}.
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DR EMBL; AF013120; AAC78689.1; -; mRNA.
DR AlphaFoldDB; O42175; -.
DR SMR; O42175; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR InterPro; IPR000074; ApoA_E.
DR Pfam; PF01442; Apolipoprotein; 1.
PE 2: Evidence at transcript level;
KW Cholesterol metabolism; HDL; Lipid metabolism; Lipid transport;
KW Reference proteome; Repeat; Secreted; Signal; Steroid metabolism;
KW Sterol metabolism; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..260
FT /note="Proapolipoprotein A-I"
FT /id="PRO_0000425348"
FT CHAIN 24..260
FT /note="Apolipoprotein A-I"
FT /id="PRO_0000001974"
FT REPEAT 64..85
FT /note="1"
FT REPEAT 87..107
FT /note="2"
FT REPEAT 108..118
FT /note="3; half-length"
FT REPEAT 119..140
FT /note="4"
FT REPEAT 141..162
FT /note="5"
FT REPEAT 163..184
FT /note="6"
FT REPEAT 185..206
FT /note="7"
FT REPEAT 207..225
FT /note="8"
FT REPEAT 226..236
FT /note="9; half-length"
FT REPEAT 237..260
FT /note="10"
FT REGION 32..63
FT /note="3 X approximate tandem repeats"
FT REGION 64..260
FT /note="10 X approximate tandem repeats"
SQ SEQUENCE 260 AA; 29634 MW; 7B31CA3F7E2C5977 CRC64;
MKFAALALAL LLAVGSHAAS MQADAPSQLD HARAVLDVYL TQVKDMSLRA VNQLDDPQYA
EFKTNLAQRI EEMYTQIKTL QGSVSPMTDS FYNTVMEVTK DTRESLNVDL EALKSSLAPQ
NEQLKQVIEK HLNDYRTLLT PIYNDYKTKH DEEMAALKTR LEPVMEELRT KIQANVEETK
AVLMPMVETV RTKVTERLES LREVVQPYVQ EYKEQMKQMY DQAQTVDTDA LRTKITPLVE
EIKVKMNAIF EIIAASVTKS
