ID   APOA2_ACIJB             Reviewed;         100 AA.
AC   P0DP50;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2017, sequence version 2.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Apolipoprotein A-II;
DE            Short=Apo-AII;
DE            Short=ApoA-II;
DE   AltName: Full=Apolipoprotein A2;
DE   Contains:
DE     RecName: Full=Proapolipoprotein A-II;
DE              Short=ProapoA-II;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein A-II;
DE   Flags: Precursor;
GN   Name=APOA2;
OS   Acinonyx jubatus (Cheetah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Acinonychinae;
OC   Acinonyx.
OX   NCBI_TaxID=32536;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Dobrynin P., Liu S., Tamazian G., Xiong Z., Yurchenko A.,
RA   Krasheninnikova K., Kliver S., Koepfli K.-P., Johnson W., Kuderna L.,
RA   Garcia-Perez R., Montero M.D.M., Godinez R., Makunin A., Komissarov A.,
RA   Brukhin V., Qiu W., Zhou L., Li F., Yi J., Driscoll C., Antunes A.,
RA   Oleksyk T.K., Eizirik E., Perelman P., Roelke' M., Wildt D., Diekhans M.,
RA   Marques-Bonet T., Schmidt-Kuntzel A., Marker L., Bhak J., Wang J.,
RA   Zhang G., Obrien S.;
RT   "Genomic legacy of the African cheetah, Acinonyx jubatus.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RA   Puppione D.L.;
RL   Unpublished observations (MAY-2017).
CC   -!- FUNCTION: May stabilize HDL (high density lipoprotein) structure by its
CC       association with lipids, and affect the HDL metabolism.
CC   -!- SUBUNIT: Monomer. Interacts with NAXE and NDRG1 (By similarity).
CC       {ECO:0000250|UniProtKB:P02652}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A2 family. {ECO:0000305}.
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DR   EMBL; LLWD01000533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_014931714.1; XM_015076228.1.
DR   AlphaFoldDB; P0DP50; -.
DR   SMR; P0DP50; -.
DR   GeneID; 106978537; -.
DR   KEGG; aju:106978537; -.
DR   CTD; 336; -.
DR   OrthoDB; 1612564at2759; -.
DR   Proteomes; UP000504626; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   InterPro; IPR006801; ApoA-II.
DR   InterPro; IPR036172; ApoA-II_sf.
DR   PANTHER; PTHR11027; PTHR11027; 1.
DR   Pfam; PF04711; ApoA-II; 1.
DR   SUPFAM; SSF82936; SSF82936; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; HDL; Lipid transport;
KW   Reference proteome; Secreted; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..100
FT                   /note="Proapolipoprotein A-II"
FT                   /id="PRO_0000440140"
FT   CHAIN           24..100
FT                   /note="Apolipoprotein A-II"
FT                   /id="PRO_0000440141"
FT   CHAIN           24..99
FT                   /note="Truncated apolipoprotein A-II"
FT                   /id="PRO_0000440142"
SQ   SEQUENCE   100 AA;  11248 MW;  DD8694739B455C37 CRC64;
     MKLLAMAVLL LTICSLEGAL VRRQAEELSL QRLVSQYFQT VTDYGKDLVE KAKGPELQAQ
     AKAYFEKTQE QLTPLVKKAG TDLINFLNNF MDLKTQPATQ