ID   APOA2_COLAN             Reviewed;         100 AA.
AC   P0DP85;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2017, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Apolipoprotein A-II;
DE            Short=Apo-AII;
DE            Short=ApoA-II;
DE   AltName: Full=Apolipoprotein A2;
DE   Contains:
DE     RecName: Full=Proapolipoprotein A-II;
DE              Short=ProapoA-II;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein A-II;
DE   Flags: Precursor;
GN   Name=APOA2;
OS   Colobus angolensis (Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=54131;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hughes D.S., Murali S., Raveendran M., Korchina V., Bandaranaike D.,
RA   Bellair M., Blankenburg K., Chao H., Dahdouli M., Dinh H., Doddapaneni H.,
RA   Gnanaolivu R., Gross S., Jayaseelan J., Jones J., Khan Z., Kovar C.,
RA   Kurapati P., Le B., Lee S., Mathew T., Narasimhan A., Okwuonu G.,
RA   Ongeri F., Osuji N., Qu C., Quiroz J., Rajbhandari K., Reid J.G.,
RA   Santibanez J., Skinner E., Wang Y., Xin Y., Han Y., Muzny D.M.,
RA   Richards S., Worley K.C., Rogers J., Gibbs R.A.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RA   Puppione D.L.;
RL   Unpublished observations (JUN-2017).
CC   -!- FUNCTION: May stabilize HDL (high density lipoprotein) structure by its
CC       association with lipids, and affect the HDL metabolism.
CC       {ECO:0000250|UniProtKB:P18656}.
CC   -!- SUBUNIT: Monomer. Interacts with NAXE and NDRG1.
CC       {ECO:0000250|UniProtKB:P02652}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A2 family. {ECO:0000305}.
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DR   EMBL; JYKR01131604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0DP85; -.
DR   SMR; P0DP85; -.
DR   OMA; LTICSFE; -.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   InterPro; IPR006801; ApoA-II.
DR   InterPro; IPR036172; ApoA-II_sf.
DR   PANTHER; PTHR11027; PTHR11027; 1.
DR   Pfam; PF04711; ApoA-II; 1.
DR   SUPFAM; SSF82936; SSF82936; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; HDL; Lipid transport; Oxidation;
KW   Phosphoprotein; Secreted; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..100
FT                   /note="Proapolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P18656"
FT                   /id="PRO_0000441385"
FT   CHAIN           24..100
FT                   /note="Apolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT                   /id="PRO_0000441386"
FT   CHAIN           24..99
FT                   /note="Truncated apolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT                   /id="PRO_0000441387"
FT   MOD_RES         49
FT                   /note="Methionine sulfoxide"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT   MOD_RES         54
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT   MOD_RES         68
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
SQ   SEQUENCE   100 AA;  11214 MW;  52B734AAB3F87AB1 CRC64;
     MKLLAATVLL LTICSLEGAL VRRQAEEPSV ESLVSQYFQT VTDYGKDLME KVKSPELQAQ
     AKAYFEKSKE QLTPLVKKAG TDLVNFLSYF VELRTQPATQ