APOA2_MACFA
ID APOA2_MACFA Reviewed; 100 AA.
AC P18656;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Apolipoprotein A-II;
DE Short=Apo-AII;
DE Short=ApoA-II;
DE AltName: Full=Apolipoprotein A2;
DE Contains:
DE RecName: Full=Proapolipoprotein A-II;
DE Short=ProapoA-II;
DE Contains:
DE RecName: Full=Truncated apolipoprotein A-II;
DE Flags: Precursor;
GN Name=APOA2;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Leukocyte;
RX PubMed=8448213; DOI=10.1016/0167-4781(93)90227-5;
RA Osada J., Garces C., Sastre J., Schaefer E.J., Ordovas J.M.;
RT "Molecular cloning and sequence of the cynomolgus monkey apolipoprotein A-
RT II gene.";
RL Biochim. Biophys. Acta 1172:340-342(1993).
RN [2]
RP PROTEIN SEQUENCE OF 24-48, AND PYROGLUTAMATE FORMATION AT GLN-24.
RX PubMed=3105581; DOI=10.1021/bi00379a037;
RA Herbert P.N., Bausserman L.L., Lynch K.M., Saritelli A.L., Kantor M.A.,
RA Nicolosi R.J., Shulman R.S.;
RT "Homologues of the human C and A apolipoproteins in the Macaca fascicularis
RT (cynomolgus) monkey.";
RL Biochemistry 26:1457-1463(1987).
CC -!- FUNCTION: May stabilize HDL (high density lipoprotein) structure by its
CC association with lipids, and affect the HDL metabolism.
CC -!- SUBUNIT: Monomer. Interacts with NAXE and NDRG1 (By similarity).
CC {ECO:0000250|UniProtKB:P02652}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}.
CC -!- TISSUE SPECIFICITY: Plasma.
CC -!- SIMILARITY: Belongs to the apolipoprotein A2 family. {ECO:0000305}.
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DR EMBL; X68360; CAA48420.1; -; Genomic_DNA.
DR PIR; S30197; S29564.
DR RefSeq; XP_005541251.1; XM_005541194.2.
DR AlphaFoldDB; P18656; -.
DR SMR; P18656; -.
DR STRING; 9541.XP_005541251.1; -.
DR Ensembl; ENSMFAT00000066259; ENSMFAP00000015732; ENSMFAG00000031068.
DR GeneID; 102119646; -.
DR KEGG; mcf:102119646; -.
DR CTD; 336; -.
DR VEuPathDB; HostDB:ENSMFAG00000031068; -.
DR eggNOG; ENOG502SVYZ; Eukaryota.
DR GeneTree; ENSGT00390000003306; -.
DR OrthoDB; 1612564at2759; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000031068; Expressed in liver and 5 other tissues.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0018206; P:peptidyl-methionine modification; ISS:UniProtKB.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISS:UniProtKB.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR GO; GO:0018158; P:protein oxidation; ISS:UniProtKB.
DR GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR InterPro; IPR006801; ApoA-II.
DR InterPro; IPR036172; ApoA-II_sf.
DR PANTHER; PTHR11027; PTHR11027; 1.
DR Pfam; PF04711; ApoA-II; 1.
DR SUPFAM; SSF82936; SSF82936; 1.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing; HDL;
KW Lipid transport; Oxidation; Phosphoprotein; Pyrrolidone carboxylic acid;
KW Reference proteome; Secreted; Signal; Transport.
FT SIGNAL 1..18
FT CHAIN 19..100
FT /note="Proapolipoprotein A-II"
FT /id="PRO_0000425353"
FT CHAIN 24..100
FT /note="Apolipoprotein A-II"
FT /evidence="ECO:0000250|UniProtKB:P02652"
FT /id="PRO_0000002006"
FT CHAIN 24..99
FT /note="Truncated apolipoprotein A-II"
FT /evidence="ECO:0000250|UniProtKB:P02652"
FT /id="PRO_0000416580"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:3105581"
FT MOD_RES 49
FT /note="Methionine sulfoxide"
FT /evidence="ECO:0000250|UniProtKB:P02652"
FT MOD_RES 54
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02652"
FT MOD_RES 68
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02652"
FT CONFLICT 26
FT /note="E -> Q (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 100 AA; 11214 MW; 52B734AAB3F87AB1 CRC64;
MKLLAATVLL LTICSLEGAL VRRQAEEPSV ESLVSQYFQT VTDYGKDLME KVKSPELQAQ
AKAYFEKSKE QLTPLVKKAG TDLVNFLSYF VELRTQPATQ
