ID   APOA2_MACMU             Reviewed;          77 AA.
AC   P02653;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 3.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Apolipoprotein A-II;
DE            Short=Apo-AII;
DE            Short=ApoA-II;
DE   AltName: Full=Apolipoprotein A2;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein A-II;
GN   Name=APOA2;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RX   PubMed=814923; DOI=10.1021/bi00651a014;
RA   Edelstein C., Noyes C., Keim P., Heinrikson R.L., Fellows R.E., Scanu A.M.;
RT   "Covalent structure of apolipoprotein A-II from Macaca mulatta serum high-
RT   density lipoproteins.";
RL   Biochemistry 15:1262-1268(1976).
CC   -!- FUNCTION: Apo A-II makes up about 20% of the protein of the HDL (high
CC       density lipoprotein) phospholipid-rich fraction in plasma.
CC   -!- SUBUNIT: Monomer. Interacts with NAXE and NDRG1 (By similarity).
CC       {ECO:0000250|UniProtKB:P02652}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}.
CC   -!- TISSUE SPECIFICITY: Plasma.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A2 family. {ECO:0000305}.
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DR   PIR; A03097; LPMQA2.
DR   AlphaFoldDB; P02653; -.
DR   SMR; P02653; -.
DR   STRING; 9544.ENSMMUP00000006019; -.
DR   eggNOG; ENOG502SVYZ; Eukaryota.
DR   HOGENOM; CLU_157351_0_0_1; -.
DR   InParanoid; P02653; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0042627; C:chylomicron; IBA:GO_Central.
DR   GO; GO:0034366; C:spherical high-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0034190; F:apolipoprotein receptor binding; IBA:GO_Central.
DR   GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR   GO; GO:0008035; F:high-density lipoprotein particle binding; IBA:GO_Central.
DR   GO; GO:0070653; F:high-density lipoprotein particle receptor binding; IBA:GO_Central.
DR   GO; GO:0055102; F:lipase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR   GO; GO:0008203; P:cholesterol metabolic process; IBA:GO_Central.
DR   GO; GO:0030301; P:cholesterol transport; IBA:GO_Central.
DR   GO; GO:0034380; P:high-density lipoprotein particle assembly; IBA:GO_Central.
DR   GO; GO:0034375; P:high-density lipoprotein particle remodeling; IBA:GO_Central.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IBA:GO_Central.
DR   GO; GO:0034374; P:low-density lipoprotein particle remodeling; IBA:GO_Central.
DR   GO; GO:0060192; P:negative regulation of lipase activity; IBA:GO_Central.
DR   GO; GO:0018206; P:peptidyl-methionine modification; ISS:UniProtKB.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; ISS:UniProtKB.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR   GO; GO:0018158; P:protein oxidation; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   GO; GO:0034370; P:triglyceride-rich lipoprotein particle remodeling; IBA:GO_Central.
DR   InterPro; IPR006801; ApoA-II.
DR   InterPro; IPR036172; ApoA-II_sf.
DR   PANTHER; PTHR11027; PTHR11027; 1.
DR   Pfam; PF04711; ApoA-II; 1.
DR   SUPFAM; SSF82936; SSF82936; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; HDL; Lipid transport; Oxidation; Phosphoprotein;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Transport.
FT   CHAIN           1..77
FT                   /note="Apolipoprotein A-II"
FT                   /id="PRO_0000181375"
FT   CHAIN           1..76
FT                   /note="Truncated apolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P83704"
FT                   /id="PRO_0000416581"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:814923"
FT   MOD_RES         26
FT                   /note="Methionine sulfoxide"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT   MOD_RES         31
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT   MOD_RES         45
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
SQ   SEQUENCE   77 AA;  8747 MW;  C00E191EB1D89200 CRC64;
     QAEEPSVESL VSQYFQTVTD YGKDLMEKVK SPELQAQAKA YFEKSKEQLT PLVKKAGTDL
     VNFLSYFVEL RTQPATQ