ID   APOA2_NASLA             Reviewed;         100 AA.
AC   P0DP86;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2017, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Apolipoprotein A-II;
DE            Short=Apo-AII;
DE            Short=ApoA-II;
DE   AltName: Full=Apolipoprotein A2;
DE   Contains:
DE     RecName: Full=Proapolipoprotein A-II;
DE              Short=ProapoA-II;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein A-II;
DE   Flags: Precursor;
GN   Name=APOA2;
OS   Nasalis larvatus (Proboscis monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Nasalis.
OX   NCBI_TaxID=43780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Abdullah M.T., Mat Daud M.H.R., Nur Aida M.T., Idris A., Croft L.,
RA   Saidin A., Alias H., Zaidan Z., Buang Z., Zainuddin R., Esa Y., Hercus R.;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RA   Puppione D.L.;
RL   Unpublished observations (JUN-2017).
CC   -!- FUNCTION: May stabilize HDL (high density lipoprotein) structure by its
CC       association with lipids, and affect the HDL metabolism.
CC       {ECO:0000250|UniProtKB:P18656}.
CC   -!- SUBUNIT: Monomer. Interacts with NAXE and NDRG1.
CC       {ECO:0000250|UniProtKB:P02652}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A2 family. {ECO:0000305}.
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DR   EMBL; JMHX01319529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0DP86; -.
DR   SMR; P0DP86; -.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   InterPro; IPR006801; ApoA-II.
DR   InterPro; IPR036172; ApoA-II_sf.
DR   PANTHER; PTHR11027; PTHR11027; 1.
DR   Pfam; PF04711; ApoA-II; 1.
DR   SUPFAM; SSF82936; SSF82936; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; HDL; Lipid transport; Oxidation;
KW   Phosphoprotein; Secreted; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..100
FT                   /note="Proapolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P18656"
FT                   /id="PRO_0000441388"
FT   CHAIN           24..100
FT                   /note="Apolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT                   /id="PRO_0000441389"
FT   CHAIN           24..99
FT                   /note="Truncated apolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT                   /id="PRO_0000441390"
FT   MOD_RES         49
FT                   /note="Methionine sulfoxide"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT   MOD_RES         54
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT   MOD_RES         68
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
SQ   SEQUENCE   100 AA;  11214 MW;  52B734AAB3F87AB1 CRC64;
     MKLLAATVLL LTICSLEGAL VRRQAEEPSV ESLVSQYFQT VTDYGKDLME KVKSPELQAQ
     AKAYFEKSKE QLTPLVKKAG TDLVNFLSYF VELRTQPATQ