ID   APOA2_ODORO             Reviewed;         100 AA.
AC   P0DM94;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   11-DEC-2013, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Apolipoprotein A-II;
DE            Short=Apo-AII;
DE            Short=ApoA-II;
DE   AltName: Full=Apolipoprotein A2;
DE   Contains:
DE     RecName: Full=Proapolipoprotein A-II;
DE              Short=ProapoA-II;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein A-II;
DE   Flags: Precursor;
GN   Name=APOA2;
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Odobenidae; Odobenus.
OX   NCBI_TaxID=9708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Foote A.D., Gilbert M.T.P., Liu Y., Lee S.L., Dugan-Rocha S., Jhangiani S.,
RA   Bandaranaike D., Batterton M., Bellair M., Bess C., Blankenburg K.,
RA   Chao H., Denson S., Dinh H., Elkadiri S., Fu Q., Hernandez B., Javaid M.,
RA   Jayaseelan J.C., Lee S., Li M., Liu X., Matskevitch T., Munidasa M.,
RA   Najjar R., Nguyen L., Ongeri F., Osuji N., Perales L., Pu L.-L., Puazo M.,
RA   Qi S., Qu C., Quiroz J., Raj R., Shafer J., Shen H., Tabassum N.,
RA   Tang L.-Y., Taylor A., Weissenberger G., Wu Y.-Q., Xin Y., Zhang Y.,
RA   Zhu Y., Zou X., Muzny D., Worley K., Gibbs R.;
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RA   Puppione D.L.;
RL   Unpublished observations (OCT-2013).
CC   -!- FUNCTION: May stabilize HDL (high density lipoprotein) structure by its
CC       association with lipids, and affect the HDL metabolism.
CC   -!- SUBUNIT: Monomer. Interacts with NAXE and NDRG1 (By similarity).
CC       {ECO:0000250|UniProtKB:P02652}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}.
CC   -!- TISSUE SPECIFICITY: Plasma.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ANOP01032616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004407970.1; XM_004407913.1.
DR   AlphaFoldDB; P0DM94; -.
DR   SMR; P0DM94; -.
DR   STRING; 9708.P0DM94; -.
DR   GeneID; 101368362; -.
DR   KEGG; oro:101368362; -.
DR   CTD; 336; -.
DR   OrthoDB; 1612564at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   InterPro; IPR006801; ApoA-II.
DR   InterPro; IPR036172; ApoA-II_sf.
DR   PANTHER; PTHR11027; PTHR11027; 1.
DR   Pfam; PF04711; ApoA-II; 1.
DR   SUPFAM; SSF82936; SSF82936; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; HDL; Lipid transport;
KW   Reference proteome; Secreted; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..100
FT                   /note="Proapolipoprotein A-II"
FT                   /id="PRO_0000425355"
FT   CHAIN           24..100
FT                   /note="Apolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT                   /id="PRO_0000424680"
FT   CHAIN           24..99
FT                   /note="Truncated apolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT                   /id="PRO_0000424749"
SQ   SEQUENCE   100 AA;  11195 MW;  E60D102254F7C40B CRC64;
     MKLLALAVLL LAVCSLEGAF VRRQAEEPNL QSLVSQYFQT MTDYGKDLVE KAKGPELQAQ
     AKAYFEKTQE QLTPLVKKAG TDLINFLSNF MDLRTQPATQ