APOA2_PANTA
ID APOA2_PANTA Reviewed; 100 AA.
AC P0DM96;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 11-DEC-2013, sequence version 1.
DT 03-AUG-2022, entry version 30.
DE RecName: Full=Apolipoprotein A-II;
DE Short=Apo-AII;
DE Short=ApoA-II;
DE AltName: Full=Apolipoprotein A2;
DE Contains:
DE RecName: Full=Proapolipoprotein A-II;
DE Short=ProapoA-II;
DE Contains:
DE RecName: Full=Truncated apolipoprotein A-II;
DE Flags: Precursor;
GN Name=APOA2;
OS Panthera tigris altaica (Siberian tiger).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae;
OC Panthera.
OX NCBI_TaxID=74533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24045858; DOI=10.1038/ncomms3433;
RA Cho Y.S., Hu L., Hou H., Lee H., Xu J., Kwon S., Oh S., Kim H.M., Jho S.,
RA Kim S., Shin Y.A., Kim B.C., Kim H., Kim C.U., Luo S.J., Johnson W.E.,
RA Koepfli K.P., Schmidt-Kuntzel A., Turner J.A., Marker L., Harper C.,
RA Miller S.M., Jacobs W., Bertola L.D., Kim T.H., Lee S., Zhou Q., Jung H.J.,
RA Xu X., Gadhvi P., Xu P., Xiong Y., Luo Y., Pan S., Gou C., Chu X.,
RA Zhang J., Liu S., He J., Chen Y., Yang L., Yang Y., He J., Liu S., Wang J.,
RA Kim C.H., Kwak H., Kim J.S., Hwang S., Ko J., Kim C.B., Kim S.,
RA Bayarlkhagva D., Paek W.K., Kim S.J., O'Brien S.J., Wang J., Bhak J.;
RT "The tiger genome and comparative analysis with lion and snow leopard
RT genomes.";
RL Nat. Commun. 4:2433-2433(2013).
RN [2]
RP IDENTIFICATION.
RA Puppione D.L.;
RL Unpublished observations (OCT-2013).
CC -!- FUNCTION: May stabilize HDL (high density lipoprotein) structure by its
CC association with lipids, and affect the HDL metabolism.
CC -!- SUBUNIT: Monomer. Interacts with NAXE and NDRG1 (By similarity).
CC {ECO:0000250|UniProtKB:P02652}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}.
CC -!- TISSUE SPECIFICITY: Plasma.
CC -!- SIMILARITY: Belongs to the apolipoprotein A2 family. {ECO:0000305}.
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DR EMBL; ATCQ01118607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007093078.1; XM_007093016.2.
DR RefSeq; XP_015397908.1; XM_015542422.1.
DR AlphaFoldDB; P0DM96; -.
DR SMR; P0DM96; -.
DR Ensembl; ENSPTIT00000027839; ENSPTIP00000023384; ENSPTIG00000019862.
DR GeneID; 102957835; -.
DR KEGG; ptg:102957835; -.
DR CTD; 336; -.
DR GeneTree; ENSGT00390000003306; -.
DR Proteomes; UP000675900; Unassembled WGS sequence.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR InterPro; IPR006801; ApoA-II.
DR InterPro; IPR036172; ApoA-II_sf.
DR PANTHER; PTHR11027; PTHR11027; 1.
DR Pfam; PF04711; ApoA-II; 1.
DR SUPFAM; SSF82936; SSF82936; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; HDL; Lipid transport;
KW Reference proteome; Secreted; Signal; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..100
FT /note="Proapolipoprotein A-II"
FT /id="PRO_0000425357"
FT CHAIN 24..100
FT /note="Apolipoprotein A-II"
FT /evidence="ECO:0000250|UniProtKB:P02652"
FT /id="PRO_0000424684"
FT CHAIN 24..99
FT /note="Truncated apolipoprotein A-II"
FT /evidence="ECO:0000250|UniProtKB:P02652"
FT /id="PRO_0000424751"
SQ SEQUENCE 100 AA; 11248 MW; AB5DF9D8EB4D6923 CRC64;
MKLLAMTVLL LTICSLEGAL VRRQAEELSL QRLVSQYFQT VTDYGKDLVE KAKGPELQAQ
AKAYFEKTQE QLTPLVKKAG TDLINFLNNF MDLKAQPATQ
