ID   APOA2_PHOVI             Reviewed;         100 AA.
AC   P0DTR2;
DT   13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2019, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Apolipoprotein A-II;
DE            Short=Apo-AII;
DE            Short=ApoA-II;
DE   AltName: Full=Apolipoprotein A2;
DE   Contains:
DE     RecName: Full=Proapolipoprotein A-II;
DE              Short=ProapoA-II;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein A-II;
DE   Flags: Precursor;
GN   Name=APOA2;
OS   Phoca vitulina (Harbor seal).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Phocidae; Phoca.
OX   NCBI_TaxID=9720;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Culibrk L., Leelakumari S., Taylor G.A., Tse K., Cheng D., Chuah E.,
RA   Kirk H., Pandoh P., Troussard A., Zhao Y., Mungall A., Moore R.,
RA   Akhurst L., Marra M.A., Haulena M., Jones S.J.M.;
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RA   Puppione D.L.;
RL   Unpublished observations (SEP-2019).
CC   -!- FUNCTION: May stabilize HDL (high density lipoprotein) structure by its
CC       association with lipids, and affect the HDL metabolism.
CC   -!- SUBUNIT: Monomer. Interacts with NAXE and NDRG1 (By similarity).
CC       {ECO:0000250|UniProtKB:P02652}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A2 family. {ECO:0000305}.
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DR   EMBL; RXNX01014799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0DTR2; -.
DR   SMR; P0DTR2; -.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   InterPro; IPR006801; ApoA-II.
DR   InterPro; IPR036172; ApoA-II_sf.
DR   PANTHER; PTHR11027; PTHR11027; 1.
DR   Pfam; PF04711; ApoA-II; 1.
DR   SUPFAM; SSF82936; SSF82936; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; HDL; Lipid transport; Oxidation;
KW   Phosphoprotein; Pyrrolidone carboxylic acid; Secreted; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..100
FT                   /note="Proapolipoprotein A-II"
FT                   /id="PRO_0000448521"
FT   CHAIN           24..100
FT                   /note="Apolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT                   /id="PRO_0000448522"
FT   CHAIN           24..99
FT                   /note="Truncated apolipoprotein A-II"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
FT                   /id="PRO_0000448523"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P02652"
SQ   SEQUENCE   100 AA;  11193 MW;  E61568539A54D86B CRC64;
     MKLLALAVLL LAVCSLEGAF VRRQAEEPNL QSLVAQYFQT MTDYGKDLLE KAKGPELQAQ
     AKAYFEKTQE QLTPLVKKAG TDLINFLSNF MDLRTQPATQ