APOA2_RAT
ID APOA2_RAT Reviewed; 102 AA.
AC P04638;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Apolipoprotein A-II;
DE Short=Apo-AII;
DE Short=ApoA-II;
DE AltName: Full=Apolipoprotein A2;
DE Contains:
DE RecName: Full=Proapolipoprotein A-II;
DE Short=ProapoA-II;
DE Flags: Precursor;
GN Name=Apoa2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3084795; DOI=10.1016/0022-2836(86)90436-5;
RA Luo C.-C., Li W.-H., Moore M.N., Chan L.;
RT "Structure and evolution of the apolipoprotein multigene family.";
RL J. Mol. Biol. 187:325-340(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-102.
RX PubMed=3093619;
RA Nagashima M., Morris G., Howlett G., Fidge N., Schreiber G.;
RT "Amino acid sequence of rat apolipoprotein A-II deduced from the nucleotide
RT sequence of cloned cDNA.";
RL J. Lipid Res. 27:706-712(1986).
CC -!- FUNCTION: May stabilize HDL (high density lipoprotein) structure by its
CC association with lipids, and affect the HDL metabolism.
CC -!- SUBUNIT: Monomer. Interacts with NAXE and NDRG1 (By similarity).
CC {ECO:0000250|UniProtKB:P02652}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02652}.
CC -!- TISSUE SPECIFICITY: Plasma.
CC -!- SIMILARITY: Belongs to the apolipoprotein A2 family. {ECO:0000305}.
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DR EMBL; X03468; CAA27185.1; -; mRNA.
DR EMBL; M28615; AAA40750.1; -; mRNA.
DR PIR; A24846; A24846.
DR RefSeq; NP_037244.1; NM_013112.1.
DR RefSeq; XP_006250300.1; XM_006250238.2.
DR RefSeq; XP_006250301.1; XM_006250239.2.
DR AlphaFoldDB; P04638; -.
DR SMR; P04638; -.
DR STRING; 10116.ENSRNOP00000004662; -.
DR iPTMnet; P04638; -.
DR PhosphoSitePlus; P04638; -.
DR PaxDb; P04638; -.
DR PRIDE; P04638; -.
DR Ensembl; ENSRNOT00000004662; ENSRNOP00000004662; ENSRNOG00000003500.
DR GeneID; 25649; -.
DR KEGG; rno:25649; -.
DR UCSC; RGD:2131; rat.
DR CTD; 336; -.
DR RGD; 2131; Apoa2.
DR eggNOG; ENOG502SVYZ; Eukaryota.
DR GeneTree; ENSGT00390000003306; -.
DR HOGENOM; CLU_157351_0_0_1; -.
DR InParanoid; P04638; -.
DR OMA; LTICSFE; -.
DR OrthoDB; 1612564at2759; -.
DR PhylomeDB; P04638; -.
DR TreeFam; TF338165; -.
DR Reactome; R-RNO-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-RNO-8957275; Post-translational protein phosphorylation.
DR Reactome; R-RNO-8963888; Chylomicron assembly.
DR Reactome; R-RNO-8963901; Chylomicron remodeling.
DR Reactome; R-RNO-975634; Retinoid metabolism and transport.
DR PRO; PR:P04638; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000003500; Expressed in liver and 18 other tissues.
DR Genevisible; P04638; RN.
DR GO; GO:0042627; C:chylomicron; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0034364; C:high-density lipoprotein particle; ISO:RGD.
DR GO; GO:0034366; C:spherical high-density lipoprotein particle; ISO:RGD.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; ISO:RGD.
DR GO; GO:0034190; F:apolipoprotein receptor binding; ISO:RGD.
DR GO; GO:0015485; F:cholesterol binding; ISO:RGD.
DR GO; GO:0120020; F:cholesterol transfer activity; IDA:RGD.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0031072; F:heat shock protein binding; ISO:RGD.
DR GO; GO:0008035; F:high-density lipoprotein particle binding; ISO:RGD.
DR GO; GO:0070653; F:high-density lipoprotein particle receptor binding; ISO:RGD.
DR GO; GO:0055102; F:lipase inhibitor activity; ISO:RGD.
DR GO; GO:0008289; F:lipid binding; ISO:RGD.
DR GO; GO:0005319; F:lipid transporter activity; ISO:RGD.
DR GO; GO:0031210; F:phosphatidylcholine binding; ISO:RGD.
DR GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; ISO:RGD.
DR GO; GO:0005543; F:phospholipid binding; ISO:RGD.
DR GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0002526; P:acute inflammatory response; IEP:RGD.
DR GO; GO:0031100; P:animal organ regeneration; IDA:RGD.
DR GO; GO:0033344; P:cholesterol efflux; ISO:RGD.
DR GO; GO:0042632; P:cholesterol homeostasis; ISO:RGD.
DR GO; GO:0008203; P:cholesterol metabolic process; ISO:RGD.
DR GO; GO:0030301; P:cholesterol transport; IDA:RGD.
DR GO; GO:0046340; P:diacylglycerol catabolic process; ISO:RGD.
DR GO; GO:0034380; P:high-density lipoprotein particle assembly; ISO:RGD.
DR GO; GO:0034384; P:high-density lipoprotein particle clearance; ISO:RGD.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; ISO:RGD.
DR GO; GO:0006869; P:lipid transport; ISO:RGD.
DR GO; GO:0042157; P:lipoprotein metabolic process; ISO:RGD.
DR GO; GO:0034374; P:low-density lipoprotein particle remodeling; ISO:RGD.
DR GO; GO:0060621; P:negative regulation of cholesterol import; ISO:RGD.
DR GO; GO:0032375; P:negative regulation of cholesterol transport; ISO:RGD.
DR GO; GO:0060695; P:negative regulation of cholesterol transporter activity; ISO:RGD.
DR GO; GO:0002719; P:negative regulation of cytokine production involved in immune response; ISO:RGD.
DR GO; GO:0060192; P:negative regulation of lipase activity; ISO:RGD.
DR GO; GO:0050995; P:negative regulation of lipid catabolic process; ISO:RGD.
DR GO; GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; ISO:RGD.
DR GO; GO:0018206; P:peptidyl-methionine modification; ISO:RGD.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; ISO:RGD.
DR GO; GO:0009395; P:phospholipid catabolic process; ISO:RGD.
DR GO; GO:0033700; P:phospholipid efflux; ISO:RGD.
DR GO; GO:0010873; P:positive regulation of cholesterol esterification; ISO:RGD.
DR GO; GO:1905920; P:positive regulation of CoA-transferase activity; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISS:UniProtKB.
DR GO; GO:0050996; P:positive regulation of lipid catabolic process; ISO:RGD.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR GO; GO:0018158; P:protein oxidation; ISO:RGD.
DR GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR GO; GO:0030300; P:regulation of intestinal cholesterol absorption; ISO:RGD.
DR GO; GO:0031647; P:regulation of protein stability; ISO:RGD.
DR GO; GO:0043627; P:response to estrogen; IEP:RGD.
DR GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
DR GO; GO:0009749; P:response to glucose; ISO:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0043691; P:reverse cholesterol transport; ISO:RGD.
DR GO; GO:0034370; P:triglyceride-rich lipoprotein particle remodeling; ISO:RGD.
DR InterPro; IPR006801; ApoA-II.
DR InterPro; IPR036172; ApoA-II_sf.
DR PANTHER; PTHR11027; PTHR11027; 1.
DR Pfam; PF04711; ApoA-II; 1.
DR SUPFAM; SSF82936; SSF82936; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; HDL; Lipid transport; Oxidation;
KW Reference proteome; Secreted; Signal; Transport.
FT SIGNAL 1..18
FT CHAIN 19..102
FT /note="Proapolipoprotein A-II"
FT /id="PRO_0000425360"
FT CHAIN 24..102
FT /note="Apolipoprotein A-II"
FT /evidence="ECO:0000250|UniProtKB:P09813"
FT /id="PRO_0000002012"
FT MOD_RES 49
FT /note="Methionine sulfoxide"
FT /evidence="ECO:0000250|UniProtKB:P02652"
SQ SEQUENCE 102 AA; 11439 MW; 94A29508DFE7A813 CRC64;
MKLLAMVALL VTICSLEGAL VRRQAAETDV QTLFSQYLQS LTDYGKDLME KAQPSEIQNQ
AKAYFQNAQE RLTPFVQRTG TNLMDFLSRL MSPEEKPAPA AK
