ID   APOA4_ACIJB             Reviewed;         382 AA.
AC   P0DSO8;
DT   31-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   31-JUL-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Apolipoprotein A-IV;
DE            Short=Apo-AIV;
DE            Short=ApoA-IV;
DE   AltName: Full=Apolipoprotein A4;
DE   Flags: Precursor;
GN   Name=APOA4;
OS   Acinonyx jubatus (Cheetah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Acinonychinae;
OC   Acinonyx.
OX   NCBI_TaxID=32536;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scott A., Pukazhenthi B., Koepfli K.-P., Mohr D., Crosier A., O'Brien S.J.,
RA   Tamazian G., Dobrynin P., Komissarov A., Kliver S., Krasheninnikova K.;
RT   "Linked reads assembly of the African cheetah.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RA   Puppione D.L.;
RL   Unpublished observations (JUN-2019).
CC   -!- FUNCTION: May have a role in chylomicrons and VLDL secretion and
CC       catabolism (By similarity). Required for efficient activation of
CC       lipoprotein lipase by ApoC-II; potent activator of LCAT (By
CC       similarity). Apoa-IV is a major component of HDL and chylomicrons (By
CC       similarity). {ECO:0000250|UniProtKB:P06727}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P06727}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P06727}.
CC   -!- DOMAIN: Nine of the thirteen 22-amino acid tandem repeats (each 22-mer
CC       is actually a tandem array of two, A and B, related 11-mers) occurring
CC       in this sequence are predicted to be highly alpha-helical, and many of
CC       these helices are amphipathic (By similarity). They may therefore serve
CC       as lipid-binding domains with lecithin:cholesterol acyltransferase
CC       (LCAT) activating abilities (By similarity).
CC       {ECO:0000250|UniProtKB:P06727}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC       {ECO:0000305}.
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DR   EMBL; QURD01003265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0DSO8; -.
DR   SMR; P0DSO8; -.
DR   Proteomes; UP000504626; Unplaced.
DR   GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   InterPro; IPR000074; ApoA_E.
DR   Pfam; PF01442; Apolipoprotein; 2.
PE   3: Inferred from homology;
KW   Chylomicron; HDL; Lipid transport; Reference proteome; Repeat; Secreted;
KW   Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..382
FT                   /note="Apolipoprotein A-IV"
FT                   /id="PRO_0000447661"
FT   REPEAT          33..54
FT                   /note="1"
FT   REPEAT          60..81
FT                   /note="2"
FT   REPEAT          82..103
FT                   /note="3"
FT   REPEAT          115..136
FT                   /note="4"
FT   REPEAT          137..158
FT                   /note="5"
FT   REPEAT          159..180
FT                   /note="6"
FT   REPEAT          181..202
FT                   /note="7"
FT   REPEAT          203..224
FT                   /note="8"
FT   REPEAT          225..246
FT                   /note="9"
FT   REPEAT          247..268
FT                   /note="10"
FT   REPEAT          269..286
FT                   /note="11"
FT   REPEAT          287..308
FT                   /note="12"
FT   REPEAT          309..330
FT                   /note="13"
FT   REGION          33..330
FT                   /note="13 X 22 AA approximate tandem repeats"
FT   REGION          362..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   382 AA;  43722 MW;  1B948A1B44C522BA CRC64;
     MFLRAVVLTL ALVAVTGARA EVSPDQVATV VWDYFSQLSN NAKEAVEHLQ QSELTQQLNA
     LFQDKLGQVN TYADNLQKKL VPFATELHER LTKDSEKLKE EIRKELEELR ARLLPHANEV
     SQKIGDNVRE LQQRLGPYAD ELRTQVNTHA EHLRRHLTSH AQRMEAVLRE NVDNLQSSLT
     PYADEFKAKI DRNIEELKGH LTPYADELKV KIDQNVEELR RSLAPYAQDV QEKLNHQLEG
     LAFQMKKNAE ELKAKITANA DELRQRLAPV VEDVRGKLRD NAKGLQESLA QLNSHLDRQV
     EEFRHNMGPY GDTFNRALVQ QVEELRQKLG SYAGGMEDHL SFLEKDLRDK VNSFFSTLKE
     KENQDMPLAL PEQEQAPGPL ES