ID   APOA4_MACFA             Reviewed;         429 AA.
AC   P33621;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Apolipoprotein A-IV;
DE            Short=Apo-AIV;
DE            Short=ApoA-IV;
DE   AltName: Full=Apolipoprotein A4;
DE   Flags: Precursor;
GN   Name=APOA4;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Leukocyte;
RX   PubMed=8448212; DOI=10.1016/0167-4781(93)90226-4;
RA   Osada J., Pocovi M., Nicolosi R.J., Schaefer E.J., Ordovas J.M.;
RT   "Nucleotide sequences of the Macaca fascicularis apolipoprotein C-III and
RT   A-IV genes.";
RL   Biochim. Biophys. Acta 1172:335-339(1993).
CC   -!- FUNCTION: May have a role in chylomicrons and VLDL secretion and
CC       catabolism. Required for efficient activation of lipoprotein lipase by
CC       ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL
CC       and chylomicrons.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P06727}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Secreted in plasma.
CC   -!- DOMAIN: Nine of the thirteen 22-amino acid tandem repeats (each 22-mer
CC       is actually a tandem array of two, A and B, related 11-mers) occurring
CC       in this sequence are predicted to be highly alpha-helical, and many of
CC       these helices are amphipathic. They may therefore serve as lipid-
CC       binding domains with lecithin:cholesterol acyltransferase (LCAT)
CC       activating abilities.
CC   -!- PTM: Phosphorylation sites are present in the extracellular medium.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X68361; CAA48421.1; -; Genomic_DNA.
DR   PIR; S30195; S29565.
DR   AlphaFoldDB; P33621; -.
DR   SMR; P33621; -.
DR   STRING; 9541.XP_005579784.1; -.
DR   eggNOG; ENOG502QSC5; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   InterPro; IPR000074; ApoA_E.
DR   Pfam; PF01442; Apolipoprotein; 2.
PE   2: Evidence at transcript level;
KW   Chylomicron; HDL; Lipid transport; Phosphoprotein; Reference proteome;
KW   Repeat; Secreted; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..429
FT                   /note="Apolipoprotein A-IV"
FT                   /id="PRO_0000001976"
FT   REPEAT          33..54
FT                   /note="1"
FT   REPEAT          60..81
FT                   /note="2"
FT   REPEAT          82..103
FT                   /note="3"
FT   REPEAT          115..136
FT                   /note="4"
FT   REPEAT          137..158
FT                   /note="5"
FT   REPEAT          159..180
FT                   /note="6"
FT   REPEAT          181..202
FT                   /note="7"
FT   REPEAT          203..224
FT                   /note="8"
FT   REPEAT          225..246
FT                   /note="9"
FT   REPEAT          247..268
FT                   /note="10"
FT   REPEAT          269..286
FT                   /note="11"
FT   REPEAT          287..308
FT                   /note="12"
FT   REPEAT          309..330
FT                   /note="13"
FT   REGION          33..330
FT                   /note="13 X 22 AA approximate tandem repeats"
FT   REGION          359..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..378
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..429
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   429 AA;  49877 MW;  3D458F551D0DB60C CRC64;
     MFLKAVVLTL ALVAVTGARA EVSADQVATV MWDYFSQLSS NAKEAVEHLQ KSELTQQLNA
     LFQDKLGEVN TYAGDLQKKL VPFATELHER LAKDSEKLKE EIRKELEEVR ARLLPHANEV
     SQKIGENVRE LQQRLEPYTD QLRTQVNTQT EQLRRQLTPY AQRMERVLRE NADSLQTSLR
     PHADQLKAKI DQNVEELKER LTPYADEFKV KIDQTVEELR RSLAPYAQDA QEKLNHQLEG
     LAFQMKKNAE ELKARISASA EELRQRLAPL AEDMRGNLRG NTEGLQKSLA ELGGHLDRHV
     EEFRLRVEPY GENFNKALVQ QMEQLRQKLG PHAGDVEGHL SFLEKDLRDK VNSFFSTFKE
     KESQDNTLSL PEPEQQREQQ QEQQQEQEQE QQQQQEQQQQ QEQQREQQQQ EQQQEQQQEQ
     VQMLAPLES