ID   APOA4_PAPAN             Reviewed;         401 AA.
AC   Q28758;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Apolipoprotein A-IV;
DE            Short=Apo-AIV;
DE            Short=ApoA-IV;
DE   AltName: Full=Apolipoprotein A4;
DE   Flags: Precursor; Fragment;
GN   Name=APOA4;
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND POLYMORPHISM.
RC   TISSUE=Intestine;
RX   PubMed=8101842; DOI=10.1016/s0021-9258(18)82308-0;
RA   Hixson J.E., Kammerer C.M., Mott G.E., Britten M.L., Birnbaum S.,
RA   Powers P.K., Vandeberg J.L.;
RT   "Baboon apolipoprotein A-IV. Identification of Lys-76-->Glu that
RT   distinguishes two common isoforms and detection of length polymorphisms at
RT   the carboxyl terminus.";
RL   J. Biol. Chem. 268:15667-15673(1993).
CC   -!- FUNCTION: May have a role in chylomicrons and VLDL secretion and
CC       catabolism. Required for efficient activation of lipoprotein lipase by
CC       ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL
CC       and chylomicrons.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P06727}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Synthesized primarily in the intestine and secreted
CC       in plasma.
CC   -!- DOMAIN: Nine of the thirteen 22-amino acid tandem repeats (each 22-mer
CC       is actually a tandem array of two, A and B, related 11-mers) occurring
CC       in this sequence are predicted to be highly alpha-helical, and many of
CC       these helices are amphipathic. They may therefore serve as lipid-
CC       binding domains with lecithin:cholesterol acyltransferase (LCAT)
CC       activating abilities.
CC   -!- PTM: Phosphorylation sites are present in the extracellular medium.
CC       {ECO:0000250}.
CC   -!- POLYMORPHISM: There are two common APOA-IV isoforms, I (shown here) and
CC       E. The I isoform is associated with higher levels of high density
CC       lipoprotein-C on a high cholesterol, saturated fat diet.
CC       {ECO:0000269|PubMed:8101842}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC       {ECO:0000305}.
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DR   EMBL; L13174; AAA35379.1; -; mRNA.
DR   AlphaFoldDB; Q28758; -.
DR   SMR; Q28758; -.
DR   STRING; 9555.ENSPANP00000011089; -.
DR   Proteomes; UP000028761; Unplaced.
DR   GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   InterPro; IPR000074; ApoA_E.
DR   Pfam; PF01442; Apolipoprotein; 2.
PE   2: Evidence at transcript level;
KW   Chylomicron; HDL; Lipid transport; Phosphoprotein; Reference proteome;
KW   Repeat; Secreted; Signal; Transport.
FT   SIGNAL          <1..4
FT                   /evidence="ECO:0000255"
FT   CHAIN           5..401
FT                   /note="Apolipoprotein A-IV"
FT                   /id="PRO_0000001978"
FT   REPEAT          17..38
FT                   /note="1"
FT   REPEAT          44..65
FT                   /note="2"
FT   REPEAT          66..87
FT                   /note="3"
FT   REPEAT          99..120
FT                   /note="4"
FT   REPEAT          121..142
FT                   /note="5"
FT   REPEAT          143..164
FT                   /note="6"
FT   REPEAT          165..186
FT                   /note="7"
FT   REPEAT          187..208
FT                   /note="8"
FT   REPEAT          209..230
FT                   /note="9"
FT   REPEAT          231..252
FT                   /note="10"
FT   REPEAT          253..270
FT                   /note="11"
FT   REPEAT          271..292
FT                   /note="12"
FT   REPEAT          293..314
FT                   /note="13"
FT   REGION          17..314
FT                   /note="13 X 22 AA approximate tandem repeats"
FT   REGION          343..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         80
FT                   /note="K -> E (in isoform E)"
FT   NON_TER         1
SQ   SEQUENCE   401 AA;  46538 MW;  0A76D1284AA9837F CRC64;
     GARAEVSADQ VATVMWDYFS QLSSNAKEAV EHLQKSELTQ QLNALFQDKL GEVNTYAGDL
     QKKLVPFATE LHERLAKDSK KLKEEIRKEL EEVRARLLPH ANEVSQKIGE NVRELQQRLE
     PYTDQLRTQV NTQTEQLRRQ LTPYAQRMER VLRENADSLQ TSLRPHADQL KAKIDQNVEE
     LKGRLTPYAD EFKVKIDQTV EELRRSLAPY AQDAQEKLNH QLEGLAFQMK KNAEELKARI
     SASAEELRQR LAPLAEDMRG NLRGNTEGLQ KSLAELGGHL DRHVEEFRLR VEPYGENFNK
     ALVQQMEQLR QKLGPHAGDV EGHLSFLEKD LRDKVNSFFS TFKEKESQDN TLSLPEPEQQ
     QEQQQEQEQQ QEQQEEQQQQ EQQQEQEQQQ EQVQMLAPLE S