ID   ILVR_CAUVC              Reviewed;         296 AA.
AC   P52670;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=HTH-type transcriptional regulator IlvR;
DE   AltName: Full=Isoleucine biosynthesis transcriptional activator;
GN   Name=ilvR; OrderedLocusNames=CC_3045;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=8113165; DOI=10.1128/jb.176.5.1275-1281.1994;
RA   Malakooti J., Ely B.;
RT   "Identification and characterization of the ilvR gene encoding a LysR-type
RT   regulator of Caulobacter crescentus.";
RL   J. Bacteriol. 176:1275-1281(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: Positively regulates the expression of the ilvD gene while
CC       negatively autoregulating its own expression.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; L24392; AAA80550.1; -; Genomic_DNA.
DR   EMBL; AE005673; AAK25007.1; -; Genomic_DNA.
DR   PIR; A53372; A53372.
DR   RefSeq; NP_421839.1; NC_002696.2.
DR   RefSeq; WP_010920881.1; NC_002696.2.
DR   AlphaFoldDB; P52670; -.
DR   SMR; P52670; -.
DR   STRING; 190650.CC_3045; -.
DR   EnsemblBacteria; AAK25007; AAK25007; CC_3045.
DR   KEGG; ccr:CC_3045; -.
DR   PATRIC; fig|190650.5.peg.3049; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_4_5; -.
DR   OMA; CECHDSA; -.
DR   BioCyc; CAULO:CC3045-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd08453; PBP2_IlvR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037412; IlvR_PBP2.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..296
FT                   /note="HTH-type transcriptional regulator IlvR"
FT                   /id="PRO_0000105654"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   296 AA;  31903 MW;  4D4FDE32C9694306 CRC64;
     MDIRQFRHFA AVAETLHFGR AAERLGITQP PLSQSIQALE KALGAPLFAR TKRHVELTAL
     GRQWLPHVLE ALAAVDALPD TARRLRDGQT GYLSLSFVST ADYSVLPDLV RRYAEAFPGV
     EIQLVEATSD VQVPAIQAGE RHAGIIIPPP NRSLPAALAY RRLVSEPLVA VTPEAWGAEG
     PLDLAALADV PLVLFPRTVA PAFHDLVTGY VAARGQPVRI VQEAIQMQTI ISLVSAGLGM
     ALAPASLRKL ARVGVRYVDL VDPPILETGL VWRRDEAAPT LQGLLRLVTE DGSAPD