ILVY_ECOLI
ID ILVY_ECOLI Reviewed; 297 AA.
AC P05827; Q2M882;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 25-MAY-2022, entry version 158.
DE RecName: Full=HTH-type transcriptional regulator IlvY;
GN Name=ilvY; OrderedLocusNames=b3773, JW3746;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=3003115; DOI=10.1016/s0021-9258(17)35955-0;
RA Wek R.C., Hatfield G.W.;
RT "Nucleotide sequence and in vivo expression of the ilvY and ilvC genes in
RT Escherichia coli K12. Transcription from divergent overlapping promoters.";
RL J. Biol. Chem. 261:2441-2450(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=1379743; DOI=10.1126/science.1379743;
RA Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.;
RT "Analysis of the Escherichia coli genome: DNA sequence of the region from
RT 84.5 to 86.5 minutes.";
RL Science 257:771-778(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 264-297.
RC STRAIN=K12;
RX PubMed=3550695; DOI=10.1093/nar/15.5.2137;
RA Lawther R.P., Wek R.C., Lopes J.M., Pereira R., Taillon B.E.,
RA Hatfield G.W.;
RT "The complete nucleotide sequence of the ilvGMEDA operon of Escherichia
RT coli K-12.";
RL Nucleic Acids Res. 15:2137-2155(1987).
CC -!- FUNCTION: This protein activates the transcription of the ilvC gene in
CC the presence of acetolactate or acetohydroxybutyrate. IlvY is also a
CC negative regulator of its own expression.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; M11689; AAA24028.1; -; Genomic_DNA.
DR EMBL; M87049; AAA67576.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77493.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77524.1; -; Genomic_DNA.
DR EMBL; M32253; AAA24025.1; -; Genomic_DNA.
DR PIR; B26287; RGECIY.
DR RefSeq; NP_418221.1; NC_000913.3.
DR RefSeq; WP_000365791.1; NZ_SSZK01000025.1.
DR AlphaFoldDB; P05827; -.
DR SMR; P05827; -.
DR BioGRID; 4263332; 4.
DR BioGRID; 852584; 4.
DR DIP; DIP-10028N; -.
DR IntAct; P05827; 4.
DR STRING; 511145.b3773; -.
DR jPOST; P05827; -.
DR PaxDb; P05827; -.
DR PRIDE; P05827; -.
DR EnsemblBacteria; AAC77493; AAC77493; b3773.
DR EnsemblBacteria; BAE77524; BAE77524; BAE77524.
DR GeneID; 948284; -.
DR KEGG; ecj:JW3746; -.
DR KEGG; eco:b3773; -.
DR PATRIC; fig|511145.12.peg.3890; -.
DR EchoBASE; EB0498; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_6_1_6; -.
DR InParanoid; P05827; -.
DR OMA; FERDNRS; -.
DR PhylomeDB; P05827; -.
DR BioCyc; EcoCyc:PD00200; -.
DR PRO; PR:P05827; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd08430; PBP2_IlvY; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR037404; IlvY_PBP2.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW Activator; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..297
FT /note="HTH-type transcriptional regulator IlvY"
FT /id="PRO_0000105655"
FT DOMAIN 1..58
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 18..37
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 297 AA; 33204 MW; E8FA6A0FC52D3815 CRC64;
MDLRDLKTFL HLAESRHFGR SARAMHVSPS TLSRQIQRLE EDLGQPLFVR DNRTVTLTEA
GEELRVFAQQ TLLQYQQLRH TIDQQGPSLS GELHIFCSVT AAYSHLPPIL DRFRAEHPSV
EIKLTTGDAA DAMEKVVTGE ADLAIAGKPE TLPGAVAFSM LENLAVVLIA PALPCPVRNQ
VSVEKPDWST VPFIMADQGP VRRRIELWFR RNKISNPMIY ATVGGHEAMV SMVALGCGVA
LLPEVVLENS PEPVRNRVMI LERSDEKTPF ELGVCAQKKR LHEPLIEAFW KILPNHK
