ID   ILVY_HAEIN              Reviewed;         292 AA.
AC   P44821;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=HTH-type transcriptional activator IlvY;
GN   Name=ilvY; OrderedLocusNames=HI_0681;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: This protein activates the transcription of the ilvC gene in
CC       the presence of acetolactate or acetohydroxybutyrate. IlvY is also a
CC       negative regulator of its own expression (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22340.1; -; Genomic_DNA.
DR   PIR; A64086; A64086.
DR   RefSeq; NP_438841.1; NC_000907.1.
DR   RefSeq; WP_005694606.1; NC_000907.1.
DR   AlphaFoldDB; P44821; -.
DR   SMR; P44821; -.
DR   STRING; 71421.HI_0681; -.
DR   DNASU; 949718; -.
DR   EnsemblBacteria; AAC22340; AAC22340; HI_0681.
DR   KEGG; hin:HI_0681; -.
DR   PATRIC; fig|71421.8.peg.712; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_1_6; -.
DR   OMA; FERDNRS; -.
DR   PhylomeDB; P44821; -.
DR   BioCyc; HINF71421:G1GJ1-716-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd08430; PBP2_IlvY; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037404; IlvY_PBP2.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..292
FT                   /note="HTH-type transcriptional activator IlvY"
FT                   /id="PRO_0000105658"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   292 AA;  33548 MW;  6FAD81E275D44244 CRC64;
     MEFTDLQIFI HLSDTKNFTK TATQNHMSPS TLSRQIQRLE DELGKTLFIR DNRQVKLTEY
     GEKFLQFAKT EWQNWQQFKQ QLKDESDELC GEIKLFCSVT ASYSHLPHVL KEFRQRYPKV
     EIQLTTGDPA LALELIQAQQ VDLALAGKPN NLPSSVVFHK IDDISLSLIA PRVACLATQL
     LQEKPIDWQQ MPFIFPVEGH ARQRIEQWLR EKQIKHPKIY ATVAGHEGIV PMVGLGFGLA
     MLPDAVIDSS PMNNQISRLN LDKPIEPFEL GICTQKRNLE QPLVRAFWAM LE