ID   ILVY_SALTI              Reviewed;         295 AA.
AC   P0A2Q3; P05988; Q9L6S5;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=HTH-type transcriptional activator IlvY;
GN   Name=ilvY; OrderedLocusNames=STY3649, t3390;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: This protein activates the transcription of the IlvC gene in
CC       the presence of acetolactate or acetohydroxybutyrate. IlvY is also a
CC       negative regulator of its own expression (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AL513382; CAD09409.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70914.1; -; Genomic_DNA.
DR   RefSeq; NP_457840.1; NC_003198.1.
DR   RefSeq; WP_000365798.1; NZ_UCTX01000015.1.
DR   AlphaFoldDB; P0A2Q3; -.
DR   SMR; P0A2Q3; -.
DR   EnsemblBacteria; AAO70914; AAO70914; t3390.
DR   KEGG; stt:t3390; -.
DR   KEGG; sty:STY3649; -.
DR   PATRIC; fig|220341.7.peg.3718; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_1_6; -.
DR   OMA; FERDNRS; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd08430; PBP2_IlvY; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037404; IlvY_PBP2.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..295
FT                   /note="HTH-type transcriptional activator IlvY"
FT                   /id="PRO_0000105656"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   295 AA;  32931 MW;  DB0460B7AA1115F3 CRC64;
     MDLRDLKTFL HLAESRHFGR SARAMHVSPS TLSRQIQRLE EDLGQPLFVR DNRTVTLTEA
     GEELRVFAQQ TLLQYQQLRH TLDQQGPSLS GELHIFCSVT AAYSHLPPIL DRFRAEHPSV
     EIKLTTGDAA DAMEKVVTGE ADLAIAGKPE TLPGAVAFSM LENLAVVLIA PALPCPVRNQ
     VSVDKPDWST VPFIMADQGP VRRRIELWFR RHKISNPQIY ATVGGHEAMV SMVALGCGVA
     LLPEVVLENS PEPVRNRVMI LERSDEKTPF ELGVCAQKKR LHEPLIDAFW KILPN