ID   ILVY_SALTY              Reviewed;         295 AA.
AC   P0A2Q2; P05988; Q9L6S5;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=HTH-type transcriptional activator IlvY;
GN   Name=ilvY; OrderedLocusNames=STM3908; ORFNames=STMD1.82;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.
RC   STRAIN=LT2;
RX   PubMed=3003115; DOI=10.1016/s0021-9258(17)35955-0;
RA   Wek R.C., Hatfield G.W.;
RT   "Nucleotide sequence and in vivo expression of the ilvY and ilvC genes in
RT   Escherichia coli K12. Transcription from divergent overlapping promoters.";
RL   J. Biol. Chem. 261:2441-2450(1986).
CC   -!- FUNCTION: This protein activates the transcription of the IlvC gene in
CC       the presence of acetolactate or acetohydroxybutyrate. IlvY is also a
CC       negative regulator of its own expression.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF33477.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF233324; AAF33477.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE006468; AAL22758.1; -; Genomic_DNA.
DR   EMBL; K03522; AAA27153.1; -; Genomic_DNA.
DR   RefSeq; NP_462799.1; NC_003197.2.
DR   RefSeq; WP_000365798.1; NC_003197.2.
DR   AlphaFoldDB; P0A2Q2; -.
DR   SMR; P0A2Q2; -.
DR   STRING; 99287.STM3908; -.
DR   PaxDb; P0A2Q2; -.
DR   EnsemblBacteria; AAL22758; AAL22758; STM3908.
DR   GeneID; 1255434; -.
DR   KEGG; stm:STM3908; -.
DR   PATRIC; fig|99287.12.peg.4130; -.
DR   HOGENOM; CLU_039613_6_1_6; -.
DR   OMA; FERDNRS; -.
DR   PhylomeDB; P0A2Q2; -.
DR   BioCyc; SENT99287:STM3908-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd08430; PBP2_IlvY; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037404; IlvY_PBP2.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..295
FT                   /note="HTH-type transcriptional activator IlvY"
FT                   /id="PRO_0000105657"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   295 AA;  32931 MW;  DB0460B7AA1115F3 CRC64;
     MDLRDLKTFL HLAESRHFGR SARAMHVSPS TLSRQIQRLE EDLGQPLFVR DNRTVTLTEA
     GEELRVFAQQ TLLQYQQLRH TLDQQGPSLS GELHIFCSVT AAYSHLPPIL DRFRAEHPSV
     EIKLTTGDAA DAMEKVVTGE ADLAIAGKPE TLPGAVAFSM LENLAVVLIA PALPCPVRNQ
     VSVDKPDWST VPFIMADQGP VRRRIELWFR RHKISNPQIY ATVGGHEAMV SMVALGCGVA
     LLPEVVLENS PEPVRNRVMI LERSDEKTPF ELGVCAQKKR LHEPLIDAFW KILPN