IM18_DROME
ID IM18_DROME Reviewed; 71 AA.
AC P82701; C4IXR8; Q59E66;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Immune-induced peptide 18;
DE Short=DIM-18;
DE Flags: Precursor;
GN Name=IM18; ORFNames=CG33706;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000305};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP PROTEIN SEQUENCE OF 27-71, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Oregon-R {ECO:0000305}; TISSUE=Hemolymph {ECO:0000305};
RA Bulet P., Charlet M., Ehret-Sabatier L.;
RL Submitted (JUL-2002) to UniProtKB.
RN [5] {ECO:0000305}
RP MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION
RP BY BACTERIA.
RC STRAIN=Oregon-R {ECO:0000303|PubMed:9736738};
RC TISSUE=Hemolymph {ECO:0000303|PubMed:9736738};
RX PubMed=9736738; DOI=10.1073/pnas.95.19.11342;
RA Uttenweiler-Joseph S., Moniatte M., Lagueux M., van Dorsselaer A.,
RA Hoffmann J.A., Bulet P.;
RT "Differential display of peptides induced during the immune response of
RT Drosophila: a matrix-assisted laser desorption ionization time-of-flight
RT mass spectrometry study.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:11342-11347(1998).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9736738}.
CC -!- TISSUE SPECIFICITY: Hemolymph (at protein level).
CC {ECO:0000269|PubMed:9736738}.
CC -!- INDUCTION: By bacterial infection. Detected within 24 hours of
CC infection. {ECO:0000269|PubMed:9736738}.
CC -!- MASS SPECTROMETRY: Mass=4626.04; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:9736738};
CC -!- MISCELLANEOUS: Not induced after bacterial challenge in strains
CC carrying a loss-of-function mutation for Toll. Constitutively expressed
CC in Toll gain-of-function mutants. {ECO:0000269|PubMed:9736738}.
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DR EMBL; AE013599; AAX52679.1; -; Genomic_DNA.
DR EMBL; AY089376; ACR44236.1; -; mRNA.
DR RefSeq; NP_001027447.1; NM_001032276.1.
DR RefSeq; NP_001286772.1; NM_001299843.1.
DR AlphaFoldDB; P82701; -.
DR IntAct; P82701; 10.
DR STRING; 7227.FBpp0100134; -.
DR PaxDb; P82701; -.
DR DNASU; 3772138; -.
DR EnsemblMetazoa; FBtr0091694; FBpp0100134; FBgn0067903.
DR EnsemblMetazoa; FBtr0343266; FBpp0309931; FBgn0067903.
DR GeneID; 3772138; -.
DR KEGG; dme:Dmel_CG33706; -.
DR CTD; 3772138; -.
DR FlyBase; FBgn0067903; IM18.
DR VEuPathDB; VectorBase:FBgn0067903; -.
DR HOGENOM; CLU_2833935_0_0_1; -.
DR OMA; QQRPFYY; -.
DR PhylomeDB; P82701; -.
DR BioGRID-ORCS; 3772138; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 3772138; -.
DR PRO; PR:P82701; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0067903; Expressed in insect adult head and 12 other tissues.
DR Genevisible; P82701; DM.
DR GO; GO:0005576; C:extracellular region; IDA:FlyBase.
DR GO; GO:0006952; P:defense response; IDA:FlyBase.
DR GO; GO:0098542; P:defense response to other organism; IMP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; HEP:FlyBase.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Immunity; Innate immunity; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..26
FT /evidence="ECO:0000255"
FT /id="PRO_0000021506"
FT PEPTIDE 27..71
FT /note="Immune-induced peptide 18"
FT /id="PRO_0000021507"
FT REGION 26..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 71 AA; 7205 MW; F11B221A278680FE CRC64;
MKLIALCCLL LLGLLGFLAA PGVASPSRHT GPGNGSGSGA GSGNPFRSPS SQQRPLYYDA
PIGKPSKTMY A
