ID   IM23_SCHHA              Reviewed;         218 AA.
AC   Q26499;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=23 kDa integral membrane protein;
DE   AltName: Full=Sh23;
OS   Schistosoma haematobium (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Kenyan;
RX   PubMed=8719163; DOI=10.1016/0166-6851(95)02490-5;
RA   Inal J., Bickle Q.;
RT   "Sequence and immunogenicity of the 23-kDa transmembrane antigen of
RT   Schistosoma haematobium.";
RL   Mol. Biochem. Parasitol. 74:217-221(1995).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; U23771; AAC46959.1; -; mRNA.
DR   RefSeq; XP_012800477.1; XM_012945023.1.
DR   AlphaFoldDB; Q26499; -.
DR   SMR; Q26499; -.
DR   OrthoDB; 1467737at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..218
FT                   /note="23 kDa integral membrane protein"
FT                   /id="PRO_0000219280"
FT   TOPO_DOM        1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..55
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        72..82
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..183
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   218 AA;  23625 MW;  5A53A0ACF22AC061 CRC64;
     MATLGTGMRC LKSCVFVLNI ICLLCSLVLI GAGAYVEVKF SQYGDNLHKV WQAAPIAIIV
     VGVIILIVSF LGCCGAIKEN VCMLYMYAFF LIILLIAELA AAIVAVVYKD RIDSEIDALM
     TGALDKPTPE ITEFMDLIQS SFHCCGAKGP QDYGPNIPAS CRGETTVYHE GCVPVFGAFL
     KRNLVIVACV AFGVCFFQLL SIVIACCLGR QIKEYENV