IM23_SCHMA
ID IM23_SCHMA Reviewed; 218 AA.
AC P19331; Q26585;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=23 kDa integral membrane protein;
DE AltName: Full=Sm23;
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2324498;
RA Wright M.D., Henkle K.J., Mitchell G.F.;
RT "An immunogenic Mr 23,000 integral membrane protein of Schistosoma mansoni
RT worms that closely resembles a human tumor-associated antigen.";
RL J. Immunol. 144:3195-3200(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NMRI;
RX PubMed=7821405; DOI=10.1006/expr.1995.1018;
RA Lee K.W., Shalaby K.A., Medhat A.M., Shi H., Yang Q., Karim A.M.,
RA Loverde P.T.;
RT "Schistosoma mansoni: characterization of the gene encoding Sm23, an
RT integral membrane protein.";
RL Exp. Parasitol. 80:155-158(1995).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; M34453; AAA29900.1; -; mRNA.
DR EMBL; L34755; AAA73525.1; -; Genomic_DNA.
DR PIR; A43522; A43522.
DR AlphaFoldDB; P19331; -.
DR SMR; P19331; -.
DR STRING; 6183.Smp_017430.1; -.
DR ABCD; P19331; 2 sequenced antibodies.
DR eggNOG; KOG3882; Eukaryota.
DR HOGENOM; CLU_055524_4_2_1; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..218
FT /note="23 kDa integral membrane protein"
FT /id="PRO_0000219282"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..55
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 151
FT /note="D -> N (in Ref. 2; AAA73525)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 218 AA; 23684 MW; 1B31BBD34C218890 CRC64;
MATLGTGMRC LKSCVFVLNI ICLLCSLVLI GAGAYVEVKF SQYGDNLHKV WQAAPIAIIV
VGVIILIVSF LGCCGAIKEN VCMLYMYAFF LVVLLIAELA AAIVAVVYKD RIDSEIDALM
TGALDKPTKE ITEFMNLIQS SFHCCGAKGP DDYRGNVPAS CKEENLTYTE GCVSVFGAFL
KRNLVIVACV AFGVCFFQLL SIVIACCLGR QIKEYENV
