ID   IM25_SCHJA              Reviewed;         224 AA.
AC   P91799;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=25 kDa integral membrane protein;
DE   AltName: Full=Sj25;
DE   AltName: Full=Sj25/TM4;
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182 {ECO:0000312|EMBL:AAB88626.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   STRAIN=Chinese;
RX   PubMed=9370241; DOI=10.1016/s0005-2736(97)00147-8;
RA   Fan J., Hooker C.W., McManus D.P., Brindley P.J.;
RT   "A new member of the transmembrane 4 superfamily (TM4SF) of proteins from
RT   schistosomes, expressed by larval and adult Schistosoma japonicum.";
RL   Biochim. Biophys. Acta 1329:18-25(1997).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- DEVELOPMENTAL STAGE: Expressed in both miracidia (larval) and adult
CC       worms. {ECO:0000269|PubMed:9370241}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; U77941; AAB88626.1; -; mRNA.
DR   AlphaFoldDB; P91799; -.
DR   SMR; P91799; -.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..224
FT                   /note="25 kDa integral membrane protein"
FT                   /id="PRO_0000219283"
FT   TOPO_DOM        1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..52
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..224
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        120
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  25550 MW;  42434C72F55BA319 CRC64;
     MKLSFTKVSL TNILILFNCL FIIFSMIVLT FGVIPQIYLL KFANILHGVR PSIFPIVCFT
     GSFVIIVACV GIIGLMKGGK CLLTMHIIAL IIATIIDIST ATLSAIKQNE FLTKAGQVLN
     DSSKLYYKNR LYATEFDLMH ITFKCCNVKN DYSLLGTLHL IPESCTHGIE FYKQQCNEPL
     NKYVRYYIDI LIYLCFIFGF IKLIYSLFTF TQRQRIFSEK TPVA