IMA1A_DICDI
ID IMA1A_DICDI Reviewed; 550 AA.
AC Q557F4; Q869V5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Probable importin subunit alpha-A;
DE AltName: Full=Karyopherin subunit alpha-A;
GN ORFNames=DDB_G0273149;
GN and
GN ORFNames=DDB_G0273595;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Functions in nuclear protein import via a substrate-importin
CC alpha-beta transport complex that passes though the nuclear pore
CC complexes (NPC). Binds specifically and directly to substrates
CC containing either a simple or bipartite NLS motif (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Forms a complex with tnpo/importin subunit beta.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus envelope
CC {ECO:0000250}.
CC -!- DOMAIN: The N-terminal hydrophilic region contains the importin beta
CC binding domain (IBB domain), which is sufficient for binding importin
CC beta and essential for nuclear protein import. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70488.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70792.1; -; Genomic_DNA.
DR RefSeq; XP_644414.1; XM_639322.1.
DR RefSeq; XP_644836.1; XM_639744.1.
DR AlphaFoldDB; Q557F4; -.
DR SMR; Q557F4; -.
DR STRING; 44689.DDB0302551; -.
DR PaxDb; Q557F4; -.
DR EnsemblProtists; EAL70488; EAL70488; DDB_G0273595.
DR EnsemblProtists; EAL70792; EAL70792; DDB_G0273149.
DR GeneID; 8618938; -.
DR GeneID; 8619039; -.
DR KEGG; ddi:DDB_G0273149; -.
DR KEGG; ddi:DDB_G0273595; -.
DR dictyBase; DDB_G0273149; -.
DR dictyBase; DDB_G0273595; -.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_018084_6_0_1; -.
DR InParanoid; Q557F4; -.
DR OMA; TITIPRM; -.
DR PhylomeDB; Q557F4; -.
DR Reactome; R-DDI-909733; Interferon alpha/beta signaling.
DR PRO; PR:Q557F4; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.20.5.690; -; 1.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR Pfam; PF00514; Arm; 5.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..550
FT /note="Probable importin subunit alpha-A"
FT /id="PRO_0000327490"
FT DOMAIN 1..56
FT /note="IBB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT REPEAT 116..155
FT /note="ARM 1"
FT REPEAT 158..198
FT /note="ARM 2"
FT REPEAT 201..241
FT /note="ARM 3"
FT REPEAT 256..297
FT /note="ARM 4"
FT REPEAT 300..339
FT /note="ARM 5"
FT REPEAT 342..381
FT /note="ARM 6"
FT REPEAT 385..424
FT /note="ARM 7"
FT REPEAT 428..467
FT /note="ARM 8"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 61592 MW; BEA7ADDC1B8160EA CRC64;
MSSRDKQDSR KKEFKKSLDS ETARRKREEN SIGIRKNARE ELMLKRRGIV QPNPSTSYQI
IVPPEVQEQF QKYENETMEN KIKNLPGLVT ALNSNDQAYV YSSLVQFRKL LSIHAYPPID
QVIECGIIPK LNQLLQCNNP KVQFESAWAL TNIASGNNRQ TQTVMESGSV PIFIQLLCAE
TTDEVKEQCA WALGNIAGDT VDSRNYLLKY GAMNALIPLL HYGEDNGATT TSANSERKIG
LIQNVVWTIS NLCRGKPQPD FSVVSQCLPA INELIRIENL PSEIYGDLCW ALSYLCDGPN
TKIQAVIDSG VVPRLVKLLE YPDSIVFTPA LRAVGNIVTG ESSQTQIVID NNGVELITRL
LAVQKKSIRK ESCWALSNIT AGEPSQIDVV VSNPKTVTTL ISLLSHSEHD IKREACWALS
NSTNNSSTKS IQTLVRHNIL KHFIDLLNSQ DLVILKIVLE GLINIIKEGE KTKTKTGVNP
YVNLISEMQG ESIIYDLQEH QSKDVYKKAF ELIEFFESSD YSDSENSEPN INQNGQYEFS
SNYNSNSINI
