ID   APOC1_ELLLU             Reviewed;          88 AA.
AC   P0DUX3;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=Apolipoprotein C-I;
DE            Short=Apo-CI;
DE            Short=ApoC-I;
DE   AltName: Full=Apolipoprotein C1;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein C-I;
DE   Flags: Precursor;
GN   Name=APOC1;
OS   Ellobius lutescens (Transcaucasian mole vole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Arvicolinae; Ellobius.
OX   NCBI_TaxID=39086;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=27510564; DOI=10.1101/gr.201665.115;
RA   Mulugeta E., Wassenaar E., Sleddens-Linkels E., Van Ijcken W.F., Heard E.,
RA   Grootegoed J.A., Just W., Gribnau J., Baarends W.M.;
RT   "Genomes of Ellobius species provide insight into the evolutionary dynamics
RT   of mammalian sex chromosomes.";
RL   Genome Res. 26:1202-1210(2016).
CC   -!- FUNCTION: Inhibitor of lipoprotein binding to the low density
CC       lipoprotein (LDL) receptor, LDL receptor-related protein, and very low
CC       density lipoprotein (VLDL) receptor. Associates with high density
CC       lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the
CC       plasma and makes up about 10% of the protein of the VLDL and 2% of that
CC       of HDL. Appears to interfere directly with fatty acid uptake and is
CC       also the major plasma inhibitor of cholesteryl ester transfer protein
CC       (CETP). Modulates the interaction of APOE with beta-migrating VLDL and
CC       inhibits binding of beta-VLDL to the LDL receptor-related protein (By
CC       similarity). Binds free fatty acids and reduces their intracellular
CC       esterification (By similarity). {ECO:0000250|UniProtKB:P02654,
CC       ECO:0000250|UniProtKB:P33047, ECO:0000250|UniProtKB:P34928}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}.
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DR   EMBL; LOJG01068708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   Gene3D; 4.10.260.30; -; 1.
DR   InterPro; IPR043081; ApoC-1_sf.
DR   InterPro; IPR006781; ApoC-I.
DR   PANTHER; PTHR16565; PTHR16565; 1.
DR   Pfam; PF04691; ApoC-I; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Secreted; Signal; Transport; VLDL.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..88
FT                   /note="Apolipoprotein C-I"
FT                   /id="PRO_0000453983"
FT   CHAIN           29..88
FT                   /note="Truncated apolipoprotein C-I"
FT                   /evidence="ECO:0000250|UniProtKB:P86336"
FT                   /id="PRO_0000453984"
SQ   SEQUENCE   88 AA;  9894 MW;  751029E7346D523E CRC64;
     MRLFISLPVL IVVLAMALEG PAPAQATPDL SSTFENLPDK LKEFGNTLED KARAAIEHIK
     QKEFLTKTRT WISETFGKMK EKIKTTFA